NRG1
NRG1，即神经调节蛋白1，别名HRG、NDF、GGF。这是一种由人类NRG1基因编码的蛋白质，属于表皮生长因子（EGF）家族。NRG1主要是通过其异构体与ErbB家族受体结合，激活多重下游信号通路，如PI3K/Akt、MAPK/ERK等，从而促进细胞增殖、分化，抑制细胞凋亡，调节能量利用，并增强血管生成。NRG1的表达和功能异常与多种疾病的发生发展相关，包括肿瘤、心血管疾病、神经精神疾病等。在肿瘤领域，NRG1基因融合是一种新兴的、潜在的致癌驱动因素，与多种肿瘤的发生发展相关，如非小细胞肺癌、肾癌、甲状腺癌等。在心血管疾病中，NRG1/ErbB信号通路在心脏的发育、心肌增殖分化及心脏传导系统的形成过程中起到了重要作用，并在心血管急慢性疾病中对心肌细胞具有保护功能。因此，NRG1被认为是这些疾病潜在的治疗靶点。
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验证数据
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(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Activity
Measured by its binding ability in a functional ELISA. Immobilized NRG1 at 2 μg/ml can bind human ERBB3(CSB-MP007765HU), the EC50 is 18.24-23.66 ng/ml.
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Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of MCF-7 cells is 2.626-7.598 ng/mL.
NRG1 Antibodies
NRG1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA016077GA01HU | NRG1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA005465 | NRG1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA970558 | NRG1 Antibody | Human | ELISA,WB |
| CSB-PA940332 | NRG1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA965247 | NRG1 Antibody | Human | ELISA,WB |
| CSB-PA09589A0Rb | NRG1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA09589B0Rb | NRG1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA09589C0Rb | NRG1 Antibody, FITC conjugated | Human | |
| CSB-PA09589D0Rb | NRG1 Antibody, Biotin conjugated | Human | ELISA |
NRG1 Proteins
NRG1 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP016077RA1 CSB-EP016077RA1 CSB-BP016077RA1 CSB-MP016077RA1 CSB-EP016077RA1-B |
Recombinant Rat Pro-neuregulin-1, membrane-bound isoform (Nrg1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF016077RA | Recombinant Rat Pro-neuregulin-1, membrane-bound isoform (Nrg1) | in vitro E.coli expression system |
NRG1 Proteins for Xenopus laevis (African clawed frog)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP526051XBE CSB-EP526051XBE CSB-BP526051XBE CSB-MP526051XBE CSB-EP526051XBE-B |
Recombinant Xenopus laevis Pro-neuregulin-1, membrane-bound isoform (nrg1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NRG1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-AP002851HU | Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial (Active) | E.Coli |
| CSB-AP002861HU | Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein (NRG1), partial (Active) | E.Coli |
| CSB-AP002921HU | Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein (NRG1),Partial (Active) | E.Coli |
| CSB-AP005731HU | Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial (Active) | E.coli |
| CSB-MP016077HU1(F6) | Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial (Active) | Mammalian cell |
| CSB-EP016077HU1 | Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial | E.coli |
| CSB-EP016077HU3(F6) | Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial | E.coli |
| CSB-YP016077HU2(F6) | Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1), partial | Yeast |
| CSB-MP016077HU-WD | Recombinant Human Pro-neuregulin-1, membrane-bound isoform (NRG1)，Partial (Active) | Mammalian cell |
