NIT2
NIT2，即腈水解酶家族成员2，别名HEL-S-8a。NIT2属于腈水解酶超家族成员，含有保守的腈水解酶结构域，是一种ω-酰胺酶。NIT2与含溴结构域蛋白1（BRD1）相互作用，抑制BRD1/HBO1介导的组蛋白H3K14乙酰化和氧化磷酸化（OXPHOS）基因表达，从而抑制化疗耐药性。NIT2是一种潜在的肿瘤抑制因子，可诱导细胞周期停滞，其表达与H3K14ac和OXPHOS呈负相关，与胃癌患者的化疗反应和预后呈正相关。NIT2的缺失或低表达导致胃癌细胞系、患者来源的胃癌类器官以及异种移植肿瘤对5-FU耐药。
热销产品
NIT2 Antibody (CSB-PA882075LA01HU)
验证数据
Western blot
All lanes: NIT2 antibody at 3μg/ml
Lane 1: Mouse heart tissue
Lane 2: A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 31 kDa
Observed band size: 31 kDa
NIT2 Antibodies
NIT2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA015823GA01HU | NIT2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA912806 | NIT2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA187627 | NIT2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA882075LA01HU | NIT2 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA882075LB01HU | NIT2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA882075LC01HU | NIT2 Antibody, FITC conjugated | Human | |
| CSB-PA882075LD01HU | NIT2 Antibody, Biotin conjugated | Human | ELISA |
NIT2 Proteins
NIT2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP882075HU CSB-EP882075HU CSB-BP882075HU CSB-MP882075HU CSB-EP882075HU-B |
Recombinant Human Omega-amidase NIT2 (NIT2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
