MPL
MPL，即巨核细胞增生性白血病病毒受体，别名Myeloproliferative Leukemia Virus Receptor、CD110等。MPL是一种表达于造血干细胞、早期髓系和淋巴系前体细胞、内皮细胞以及某些肿瘤细胞表面的细胞表面受体。它属于肿瘤坏死因子受体超家族成员，由人体细胞自身的基因编码。MPL的作用机制主要涉及与多种配体结合，如TPO（血小板生成素）、ELN（内皮细胞白血病抑制因子）等，这些配体的结合能够激活MPL，进而触发下游的JAK2/STAT、MAPK等信号通路，促进巨核细胞的增殖和分化，影响血小板的生成。MPL在正常的造血过程中发挥着关键作用，尤其是在血小板的生成和功能的维持中。MPL的激活可以促进巨核细胞的增殖和成熟，从而增加血小板的产生。此外，MPL还参与了对炎症反应、血管生成和免疫调节等过程的调控。MPL的功能异常与某些骨髓增生性疾病的发生发展有关，如原发性血小板增多症、骨髓增生异常综合征等。因此，MPL是血液学研究和相关疾病治疗中的一个潜在靶点。
热销产品
Recombinant Human Thrombopoietin receptor (MPL), partial (CSB-EP014755HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MPL Antibody (CSB-PA014755LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA014755LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA014755LA01HU at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA014755LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
MPL Antibodies
MPL for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA005848 | MPL Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA010219 | MPL Antibody | Human | WB, ELISA |
| CSB-PA014755LA01HU | MPL Antibody | Human | ELISA, IHC, IF |
| CSB-PA014755LB01HU | MPL Antibody, HRP conjugated | Human | ELISA |
| CSB-PA014755LC01HU | MPL Antibody, FITC conjugated | Human |
MPL Proteins
MPL Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP014755HU | Recombinant Human Thrombopoietin receptor (MPL), partial | Yeast |
| CSB-EP014755HU | Recombinant Human Thrombopoietin receptor (MPL), partial | E.coli |
| CSB-BP014755HU CSB-MP014755HU CSB-EP014755HU-B |
Recombinant Human Thrombopoietin receptor (MPL), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MPL Proteins for Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP332898LPY CSB-EP332898LPY CSB-BP332898LPY CSB-MP332898LPY CSB-EP332898LPY-B |
Recombinant Listeria monocytogenes serovar 1/2a Zinc metalloproteinase (mpl) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MPL Proteins for Listeria monocytogenes
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP333848LGW CSB-EP333848LGW CSB-BP333848LGW CSB-MP333848LGW CSB-EP333848LGW-B |
Recombinant Zinc metalloproteinase (mpl) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MPL Proteins for Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP337588HTA CSB-EP337588HTA CSB-BP337588HTA CSB-MP337588HTA CSB-EP337588HTA-B |
Recombinant Haemophilus influenzae UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (mpl) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MPL Proteins for Escherichia coli (strain K12)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP339870ENV CSB-EP339870ENV CSB-BP339870ENV CSB-MP339870ENV CSB-EP339870ENV-B |
Recombinant Escherichia coli UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (mpl) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MPL Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP600093MO CSB-EP600093MO CSB-BP600093MO CSB-MP600093MO CSB-EP600093MO-B |
Recombinant Mouse Thrombopoietin receptor (Mpl) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
