MERTK
MERTK，即MER原癌基因酪氨酸激酶（MerTK），别名PROS1R、TYRO3、Axl-likeprotein等。它是一种受体酪氨酸激酶，属于TAM（TYRO3、AXL、MERTK）家族成员之一。MERTK在多种组织中表达，包括巨噬细胞和视网膜色素上皮细胞。其作用机制涉及与磷脂酰丝氨酸（PS）暴露的凋亡细胞结合，介导巨噬细胞的吞噬作用，促进细胞凋亡的清除，同时参与调节炎症反应和免疫应答。MERTK对于维持组织稳态、促进损伤修复、调节免疫反应具有重要作用。MERTK的异常表达与多种疾病相关，包括视网膜色素变性、某些类型的癌症以及免疫相关疾病。在肿瘤微环境中，MERTK的表达与肿瘤免疫逃逸有关，通过调节肿瘤相关巨噬细胞（TAMs）的吞噬作用，影响肿瘤免疫原性和抗肿瘤免疫。MERTK是癌症治疗中一个潜在的药物靶点。
热销产品
Recombinant Human Tyrosine-protein kinase Mer (MERTK), partial (Active) (CSB-MP621519HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized MERTK at 2 μg/ml can bind anti-MERTK antibody（CSB-RA621519A1HU）, the EC50 is 32.95-48.25 ng/mL.
MERTK Recombinant Monoclonal Antibody (CSB-RA621519A1HU)
验证数据
The Binding Activity of MERTK with anti-MERTK antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized MERTK at 2 μg/mL can bind anti-MERTK antibody(CSB-RA621519A1HU), the EC50 is 41.31-72.08 ng/mL.
MERTK Antibodies
MERTK for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA253602 | MERTK Antibody | Human | ELISA,WB |
| CSB-PA621519ESR1HU | MERTK Antibody | Human, Mouse | ELISA, WB |
| CSB-PA621519ESR2HU | MERTK Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA003228 | MERTK Antibody | Human | WB, ELISA |
| CSB-PA999740 | MERTK Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA668039 | MERTK Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA621519A1HU | MERTK Recombinant Monoclonal Antibody | Human | ELISA |
| CSB-MA621519A0m | MERTK Monoclonal Antibody | Human | ELISA, WB, IHC, IF, FC |
MERTK Proteins
MERTK Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP013706RA CSB-EP013706RA CSB-BP013706RA CSB-EP013706RA-B |
Recombinant Rat Tyrosine-protein kinase Mer (Mertk), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP013706RA | Recombinant Rat Tyrosine-protein kinase Mer (Mertk), partial | Mammalian cell |
MERTK Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP621519HU CSB-EP621519HU CSB-BP621519HU CSB-EP621519HU-B |
Recombinant Human Tyrosine-protein kinase Mer (MERTK), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP621519HU | Recombinant Human Tyrosine-protein kinase Mer (MERTK), partial (Active) | Mammalian cell |
MERTK Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP723346MO1 CSB-EP723346MO CSB-BP723346MO CSB-EP723346MO1-B |
Recombinant Mouse Tyrosine-protein kinase Mer (Mertk), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP723346MO | Recombinant Mouse Tyrosine-protein kinase Mer (Mertk), partial (Active) | Mammalian cell |
