LGALS8
LGALS8，即半乳糖凝集素8，别名Gal-8、PCTA1、PCTA-1、Po66-CBP。它是由人类LGALS8基因编码的蛋白质，属于半乳糖凝集素家族。半乳糖凝集素是一类能够结合β-半乳糖苷的动物凝集素，具有保守的碳水化合物识别结构域，涉及许多基本生物学功能，如发育、分化、细胞间粘附、细胞与基质的相互作用、生长调节、细胞凋亡和RNA剪接。LGALS8能够诱导肿瘤免疫抑制，通过分析动物模型和临床数据发现，LGALS8表达的肿瘤中，抑制性免疫细胞（如Tregs和MDSCs）扩增，而CD8+细胞减少，直接证明了LGALS8调节肿瘤免疫微环境的能力。此外，LGALS8与淋巴结转移和免疫表型相关，其表达水平与肿瘤的预后和进展有关，表明它在肿瘤发展中的重要作用。
热销产品
Recombinant Human Galectin-8 (LGALS8) (Active) (CSB-EP012894HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized SLC31A1 at 5 μg/ml can bind human LGALS8, the EC50 of human LGALS8 is 373.90-524.30 μg/ml.
LGALS8 Antibody (CSB-PA012894ESR2HU)
验证数据
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA012894ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA012894ESR2HU at dilution of 1:100
LGALS8 Antibodies
LGALS8 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA067074 | LGALS8 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA009823 | LGALS8 Antibody | Human,Mouse | WB, IHC, IF, ELISA |
| CSB-PA276679 | LGALS8 Antibody | Human | ELISA,IHC |
| CSB-PA130656 | LGALS8 Antibody | Human | ELISA,IHC |
| CSB-PA012894ESR2HU | LGALS8 Antibody | Human | ELISA, IHC |
LGALS8 Proteins
LGALS8 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP012894HU CSB-BP012894HU CSB-MP012894HU CSB-EP012894HU-B |
Recombinant Human Galectin-8 (LGALS8) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP012894HU | Recombinant Human Galectin-8 (LGALS8) (Active) | E.coli |
LGALS8 ELISA Kit
LGALS8 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL012894HU | Human Galectin-8(LGALS8) ELISA kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
