LGALS3BP
LGALS3BP编码的蛋白全称为半乳糖凝集素-3结合蛋白(Galectin-3 binding protein),常被简称为MAC-2BP或90K蛋白,在UniProt数据库中也被标注为Lectin galactoside-binding soluble 3 binding protein。该蛋白是一种分泌型糖蛋白,广泛参与细胞间相互作用与免疫调节,通过与半乳糖凝集素家族成员(如Galectin-3)结合,介导细胞黏附、炎症反应及肿瘤微环境调控。研究发现其在多种癌症中异常高表达,包括乳腺癌、肺癌和肝癌,可能与肿瘤转移、血管生成及免疫逃逸相关。此外,该蛋白在病毒感染中发挥双重作用,既能通过增强干扰素应答抑制HIV复制,又能作为HCV病毒颗粒的附着因子促进感染。在自身免疫性疾病如系统性红斑狼疮患者血清中,其水平显著升高。近年来,针对LGALS3BP的药物开发聚焦于癌症治疗领域,已有单克隆抗体药物进入临床前研究,试图通过阻断其与Galectin-3的相互作用抑制肿瘤进展。同时,其作为生物标志物的潜力也在液体活检技术中受到关注,特别是在肝癌早期诊断和预后评估方面显示出应用价值。
热销产品
Recombinant Human Galectin-3-binding protein (LGALS3BP) (CSB-EP012888HU)
验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
LGALS3BP Antibody (CSB-PA594413)
验证数据

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA594413(LGALS3BP Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA594413(LGALS3BP Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
Human Galectin-3-binding protein(LGALS3BP) ELISA kit (CSB-EL012888HU)
验证数据

货号:CSB-EL012888HU
规格:96T/48T
灵敏度:0.39 ng/mL
检测范围:1.56 ng/mL-100 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
LGALS3BP Antibodies
LGALS3BP for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA012888GA01HU | LGALS3BP Antibody | Human | ELISA,WB |
CSB-PA594413 | LGALS3BP Antibody | Human | ELISA,IHC |
CSB-PA667994 | LGALS3BP Antibody | Human,Mouse | WB,ELISA |
LGALS3BP Proteins
LGALS3BP Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-EP012888HU | Recombinant Human Galectin-3-binding protein (LGALS3BP) | E.coli |
LGALS3BP ELISA Kit
LGALS3BP ELISA Kit for Homo sapiens (Human)
产品货号 | 产品名称 | 样本类型 | 灵敏度 |
---|---|---|---|
CSB-EL012888HU | Human Galectin-3-binding protein(LGALS3BP) ELISA kit | serum, plasma, tissue homogenates | 0.39 ng/mL |