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LGALS3BP

LGALS3BP编码的蛋白全称为半乳糖凝集素-3结合蛋白(Galectin-3 binding protein),常被简称为MAC-2BP或90K蛋白,在UniProt数据库中也被标注为Lectin galactoside-binding soluble 3 binding protein。该蛋白是一种分泌型糖蛋白,广泛参与细胞间相互作用与免疫调节,通过与半乳糖凝集素家族成员(如Galectin-3)结合,介导细胞黏附、炎症反应及肿瘤微环境调控。研究发现其在多种癌症中异常高表达,包括乳腺癌、肺癌和肝癌,可能与肿瘤转移、血管生成及免疫逃逸相关。此外,该蛋白在病毒感染中发挥双重作用,既能通过增强干扰素应答抑制HIV复制,又能作为HCV病毒颗粒的附着因子促进感染。在自身免疫性疾病如系统性红斑狼疮患者血清中,其水平显著升高。近年来,针对LGALS3BP的药物开发聚焦于癌症治疗领域,已有单克隆抗体药物进入临床前研究,试图通过阻断其与Galectin-3的相互作用抑制肿瘤进展。同时,其作为生物标志物的潜力也在液体活检技术中受到关注,特别是在肝癌早期诊断和预后评估方面显示出应用价值。

热销产品

Recombinant Human Galectin-3-binding protein (LGALS3BP) (CSB-EP012888HU)

验证数据

CSB-EP012888HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LGALS3BP Antibody (CSB-PA594413)

验证数据

CSB-PA594413

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA594413(LGALS3BP Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

CSB-PA594413

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA594413(LGALS3BP Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

Human Galectin-3-binding protein(LGALS3BP) ELISA kit (CSB-EL012888HU)

验证数据

CSB-EL012888HU 标准曲线

货号:CSB-EL012888HU

规格:96T/48T

灵敏度:0.39 ng/mL

检测范围:1.56 ng/mL-100 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

LGALS3BP Antibodies

LGALS3BP for Homo sapiens (Human)

LGALS3BP Proteins

LGALS3BP Proteins for Homo sapiens (Human)

LGALS3BP ELISA Kit

LGALS3BP ELISA Kit for Homo sapiens (Human)