LAIR1
LAIR1，即白细胞相关免疫球蛋白样受体1，别名CD305、LAIR-1。它主要在多种免疫细胞上表达，包括自然杀伤细胞、T细胞和B细胞。LAIR1的作用机制涉及与其高亲和力配体胶原蛋白的结合，这一结合能够诱导LAIR1上的免疫受体酪氨酸基抑制基序（ITIMs）的自体磷酸化，进而招募如Src同源区域含磷酸酶SHP-1和SHP-2等磷酸酶，调节负向信号。LAIR1作为一种抑制性受体，通过调节免疫反应，防止自身细胞被裂解，同时在肿瘤微环境中，胶原蛋白/LAIR1信号在下调抗肿瘤反应中发挥重要作用。LAIR1的异常表达与多种癌症的发展相关，包括白血病、卵巢癌、肾癌、口腔鳞状细胞癌和肝细胞癌，其在肿瘤免疫逃逸和免疫治疗中可能作为潜在的生物标志物。
热销产品
LAIR1 Antibody (CSB-PA012721LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA012721LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA012721LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA012721LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
LAIR1 Antibodies
LAIR1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA006294 | LAIR1 Antibody | Human | WB, ELISA |
| CSB-PA088669 | LAIR1 Antibody | Human | ELISA,IHC |
| CSB-PA694004 | LAIR1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA012721LA01HU | LAIR1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA012721LB01HU | LAIR1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012721LC01HU | LAIR1 Antibody, FITC conjugated | Human | |
| CSB-PA012721LD01HU | LAIR1 Antibody, Biotin conjugated | Human | ELISA |
LAIR1 Proteins
LAIR1 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP012721RA1 CSB-EP012721RA1 CSB-BP012721RA1 CSB-MP012721RA1 CSB-EP012721RA1-B |
Recombinant Rat Leukocyte-associated immunoglobulin-like receptor 1 (Lair1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF012721RA | Recombinant Rat Leukocyte-associated immunoglobulin-like receptor 1 (Lair1) | in vitro E.coli expression system |
LAIR1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP012721HU CSB-EP012721HU CSB-BP012721HU CSB-MP012721HU CSB-EP012721HU-B |
Recombinant Human Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LAIR1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP012721MO CSB-EP012721MO CSB-BP012721MO CSB-MP012721MO CSB-EP012721MO-B |
Recombinant Mouse Leukocyte-associated immunoglobulin-like receptor 1 (Lair1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
