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KLK3

KLK3全称为激肽释放酶相关肽酶3,又称前列腺特异性抗原(PSA),是人体精液中的重要成分。该蛋白由前列腺上皮细胞分泌,主要功能是通过分解精囊凝固蛋白促进精子液化,在生殖过程中起关键作用。KLK3表达受雄激素严格调控,临床上常作为前列腺癌筛查的核心生物标志物。当血清PSA水平异常升高时,常提示前列腺增生、炎症或恶性肿瘤可能,但需结合直肠指检、影像学检查综合判断。
PSA可通过裂解胰岛素样生长因子结合蛋白(IGFBP)影响细胞增殖通路,与肿瘤转移存在潜在关联。基于该蛋白特性开发的诊断试剂已广泛应用于前列腺癌早期检测,全球年检测量超过1亿人次。治疗领域,靶向PSA的放射性核素疗法(如177Lu-PSMA)在晚期前列腺癌患者中展现出显著疗效,目前FDA已批准Pluvicto®等药物上市。我国自主研发的PSA抑制剂也进入Ⅱ期临床试验阶段。

热销产品

KLK3 Recombinant Monoclonal Antibody (CSB-RA548583A0HU)

验证数据

CSB-RA548583A0HU

IHC image of CSB-RA548583A0HU diluted at 1:100 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

KLK3 Antibodies

KLK3 for Homo sapiens (Human)

KLK3 ELISA Kit

KLK3 ELISA Kit for Homo sapiens (Human)