KIF20A
KIF20A（驱动蛋白家族成员20A）也被称为Rab6相互作用驱动蛋白样蛋白或MKLP2，是一种参与细胞有丝分裂的关键分子马达蛋白。KIF20A通过调控微管动态参与胞质分裂过程，负责将细胞膜成分与染色体分离所需的物质定向运输至分裂沟区域。KIF20A在多种恶性肿瘤中异常高表达，包括肝癌、胰腺癌和三阴性乳腺癌，其过表达会加速肿瘤细胞增殖并促进远处转移，已成为癌症治疗的重要潜在靶点。目前针对该靶点的药物开发聚焦于小分子抑制剂和单克隆抗体，其中日本研发的KIF20A多肽疫苗已在肝癌临床前试验中显示出抑制肿瘤生长的效果，而特异性抑制剂Paprotrain等化合物正进行抗肿瘤活性评估。KIF20A在正常组织中低表达的特性为靶向治疗提供了较好的安全性窗口。
热销产品
KIF20A Antibody (CSB-PA012321LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA012321LA01HU at dilution of 1:100
Immunoprecipitating KIF20A in 293 whole cell lysate
Lane 1: Rabbit control IgG (1μg) instead of CSB-PA012321LA01HU in 293 whole cell lysate.
For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA012321LA01HU (6μg) + 293 whole cell lysate (500μg)
Lane 3: 293 whole cell lysate (10μg)
KIF20A Antibodies
KIF20A for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA012321GA01HU | KIF20A Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA006385 | Phospho-KIF20A (S528) Antibody | Human | WB, IHC, ELISA |
| CSB-PA006386 | KIF20A Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA099632 | KIF20A Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA966542 | KIF20A Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA012321LA01HU | KIF20A Antibody | Human | ELISA, IHC, IP |
| CSB-PA012321LB01HU | KIF20A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA012321LC01HU | KIF20A Antibody, FITC conjugated | Human | |
| CSB-PA012321LD01HU | KIF20A Antibody, Biotin conjugated | Human | ELISA |
KIF20A Proteins
KIF20A Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP012321HU CSB-EP012321HU CSB-BP012321HU CSB-MP012321HU CSB-EP012321HU-B |
Recombinant Human Kinesin-like protein KIF20A (KIF20A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
