KIF18A
KIF18A，即驱动蛋白家族成员18A。别名CD319。它在细胞内主要位于细胞质和细胞核中，由898个氨基酸残基组成，分子量约为100kDa。KIF18A的作用机制涉及其作为kinesin-8家族成员，依靠水解ATP释放的能量，以微管为轨道向正极方向运动，调控微管的动态不稳定性，发挥类似于微管解聚酶的活性。KIF18A对维持染色体稳定性和控制有丝分裂过程中的染色体排列至关重要，其功能异常可能导致细胞转化和致癌。多项研究表明，KIF18A在多种癌细胞中具有高表达，与乳腺癌、透明细胞肾癌和结肠癌患者的预后相关，参与肝细胞癌的侵袭和转移，并与细胞增殖、肿瘤分期和多发性肿瘤的预后相关。KIF18A是一种可能的癌症预后生物标志物，也是抗有丝分裂治疗的潜在靶点。
热销产品
KIF18A Antibody (CSB-PA847753LA01HU)
验证数据
Immunofluorescence staining of A549 cells with CSB-PA847753LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
KIF18A Antibodies
KIF18A for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA012315GA01HU | KIF18A Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA847753LA01HU | KIF18A Antibody | Human | ELISA, IF |
| CSB-PA847753LB01HU | KIF18A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA847753LC01HU | KIF18A Antibody, FITC conjugated | Human | |
| CSB-PA847753LD01HU | KIF18A Antibody, Biotin conjugated | Human | ELISA |
KIF18A Proteins
KIF18A Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP847753HU CSB-EP847753HU CSB-BP847753HU CSB-MP847753HU CSB-EP847753HU-B |
Recombinant Human Kinesin-like protein KIF18A (KIF18A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
