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JAK3

JAK3,即Janus激酶3,别名Janus Kinase3、L-JAK,是JAK激酶家族中的一个关键成员,主要在免疫系统的细胞中发挥作用。作为一种非受体型酪氨酸激酶,JAK3通过参与JAK-STAT信号通路,调控细胞因子介导的细胞增殖、分化和凋亡等过程。JAK3的活性对维持免疫平衡至关重要,其异常表达或功能失调与多种自身免疫性疾病,如类风湿性关节炎、系统性红斑狼疮等有关。此外,JAK3也是癌症治疗中的潜在靶点,针对JAK3的抑制剂,如托法替布,已被批准用于治疗某些自身免疫性疾病,展现出良好的疗效和安全性。因此,JAK3在药物开发和疾病治疗中具有重要的生物学意义和临床应用价值。

热销产品

JAK3 Recombinant Monoclonal Antibody (CSB-RA206737A0HU)

验证数据

CSB-RA206737A0HU

IHC image of CSB-RA206737A0HU diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

JAK3 Antibodies

JAK3 for Homo sapiens (Human)

JAK3 Proteins

JAK3 Proteins for Homo sapiens (Human)

JAK3 Proteins for Mus musculus (Mouse)

JAK3 Proteins for Rattus norvegicus (Rat)