JAG1
JAG1，即Jagged1蛋白，别名AGS、AHD、AWS、HJ1、AGS1、DCHE、CD339、JAGL1、CMT2HH。
JAG1在成人和胎儿组织中广泛表达，其表达在宫颈鳞状细胞癌中上调，并在骨髓细胞系HS-27a中表达。
JAG1是多个Notch受体的配体，参与调节Notch信号传导。JAG1在哺乳动物心血管发育的早期和晚期阶段都有所涉及，它通过抑制成肌细胞分化和增强成纤维细胞生长因子诱导的血管生成来发挥作用。
JAG1与多种疾病相关，包括Alagille综合征和某些类型的癌症，如乳腺癌和肾上腺皮质癌。JAG1的突变与Alagille综合征相关，这是一种主要影响肝脏、心脏、骨骼、眼睛、面部、肾脏和血管系统的多系统显性障碍，表明JAG1的功能丧失是导致这些组织疾病的原因。
热销产品
Recombinant Human Protein jagged-1 (JAG1), partial (CSB-MP011927HUh6)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
JAG1 Antibody (CSB-PA01949A0Rb)
验证数据
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA01949A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA01949A0Rb at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA01949A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Protein jagged-1(JAG1) ELISA kit (CSB-EL011927HU)
验证数据
货号：CSB-EL011927HU
规格：96T/48T
灵敏度：0.039 ng/mL
检测范围：0.156 ng/mL-10 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
JAG1 Antibodies
JAG1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA005638 | JAG1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA969766 | JAG1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA234352 | JAG1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA01949A0Rb | JAG1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA01949B0Rb | JAG1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA01949C0Rb | JAG1 Antibody, FITC conjugated | Human | |
| CSB-PA01949D0Rb | JAG1 Antibody, Biotin conjugated | Human | ELISA |
JAG1 Proteins
JAG1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011927HU CSB-EP011927HU CSB-BP011927HU CSB-MP011927HU CSB-EP011927HU-B |
Recombinant Human Protein jagged-1 (JAG1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP011927HUh6 | Recombinant Human Protein jagged-1 (JAG1), partial | Mammalian cell |
JAG1 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP730923RA CSB-EP730923RA CSB-BP730923RA CSB-MP730923RA CSB-EP730923RA-B |
Recombinant Rat Protein jagged-1 (Jag1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
JAG1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP870758MO CSB-BP870758MO CSB-MP870758MO CSB-EP870758MO-B |
Recombinant Mouse Protein jagged-1 (Jag1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP870758MO | Recombinant Mouse Protein jagged-1 (Jag1), partial | E.coli |
JAG1 ELISA Kit
JAG1 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL011927HU | Human Protein jagged-1(JAG1) ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
