ITK
ITK，即白细胞介素-2诱导型T细胞激酶，别名Emt、Tsk。它是由人类ITK基因编码的蛋白质，主要在T细胞中表达。ITK的作用机制涉及T细胞受体（TCR）激活后的信号传导过程，其通过被招募到细胞膜上，靠近被激活的TCR受体，并在那里被LCK激酶磷酸化。磷酸化导致ITK自磷酸化和完全激活。一旦激活，ITK会磷酸化PLCG1，导致这种脂酶的激活和随后对其底物的切割。进而内质网释放钙离子到细胞质中，激活T细胞的核因子（NFAT）转移到细胞核中执行其转录功能。ITK对调节适应性免疫反应至关重要，它调控传统T细胞和非传统NKT细胞的发育、功能和分化。ITK对Th2和Th17细胞的发育和效应功能具有重要作用，缺乏ITK的小鼠被证明不易患哮喘。
热销产品
ITK Recombinant Monoclonal Antibody (CSB-RA954682A0HU)
验证数据
IHC image of CSB-RA954682A0HU diluted at 1:100 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
ITK Antibodies
ITK for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA011900GA01HU | ITK Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA011277 | Phospho-ITK (Y512) Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA087882 | ITK Antibody | Human,Mouse | ELISA,IHC |
| CSB-RA954682A0HU | ITK Recombinant Monoclonal Antibody | Human | ELISA, IHC |
ITK Proteins
ITK Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP600145HU CSB-EP600145HU CSB-BP600145HU CSB-MP600145HU CSB-EP600145HU-B |
Recombinant Human Tyrosine-protein kinase ITK/TSK (ITK) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
