ITGB7
ITGB7是一种介导细胞间黏附的重要膜蛋白，其全称为整合素β7亚基，临床上常被称为CD103或淋巴细胞归巢受体。该蛋白广泛分布于肠道、皮肤等黏膜组织的免疫细胞表面，通过与整合素α4或αE亚基配对形成异源二聚体，协助淋巴细胞定向迁移至炎症部位。ITGB7功能异常与多种免疫性疾病密切相关，例如在溃疡性结肠炎患者的病变肠道中，整合素β7阳性淋巴细胞异常聚集会加剧组织损伤。ITGB7在胃肠道T细胞淋巴瘤中呈现高表达特征，可能成为鉴别诊断的生物标志物。
针对整合素β7的药物开发聚焦于阻断其介导的病理过程。全球已有多个单克隆抗体进入临床试验阶段，其中Etrolizumab在克罗恩病治疗中展现出调节肠道炎症的潜力。部分小分子抑制剂通过干扰蛋白构象变化，正在探索对特应性皮炎等疾病的干预效果。这类药物需精准平衡免疫抑制与黏膜屏障保护的双重需求，目前仍有待突破性进展。
热销产品
Recombinant Human Integrin beta-7 (ITGB7), partial (CSB-EP011891HU2)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ITGB7 Antibody (CSB-PA011891ESR1HU)
验证数据
Western blot
All lanes: ITGB7 antibody at 5.04μg/ml
Lane 1: MCF-7 whole cell lysate
Lane 2: HepG2 whole cell lysate
Lane 3: A549 whole cell lysate
Lane 4: K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 87, 72 kDa
Observed band size: 87 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA011891ESR1HU at dilution of 1:100
ITGB7 Antibodies
ITGB7 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA011891GA01HU | ITGB7 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA939542 | ITGB7 Antibody | Human | ELISA,WB,IHC |
| CSB-PA588701 | ITGB7 Antibody | Human | ELISA,IHC |
| CSB-PA011891ESR1HU | ITGB7 Antibody | Human | ELISA, WB, IHC |
| CSB-PA011891ESR2HU | ITGB7 Antibody | Human | ELISA, IHC |
ITGB7 Proteins
ITGB7 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011891MO1 CSB-EP011891MO1 CSB-BP011891MO1 CSB-MP011891MO1 CSB-EP011891MO1-B |
Recombinant Mouse Integrin beta-7 (Itgb7), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011891MO | Recombinant Mouse Integrin beta-7 (Itgb7) | in vitro E.coli expression system |
ITGB7 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011891HU1 CSB-BP011891HU1 CSB-MP011891HU1 CSB-EP011891HU1-B |
Recombinant Human Integrin beta-7 (ITGB7), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011891HU | Recombinant Human Integrin beta-7 (ITGB7) | in vitro E.coli expression system |
| CSB-EP011891HU1 | Recombinant Human Integrin beta-7 (ITGB7), partial | E.coli |
| CSB-EP011891HU2 | Recombinant Human Integrin beta-7 (ITGB7), partial | E.coli |
ITGB7 ELISA Kit
ITGB7 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL011891HU | Human Integrin beta-7(ITGB7) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
