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ITGB6

ITGB6,即整合素β6,别名Integrin beta-6。这是一种在上皮细胞中表达的蛋白质,通常与整合素亚基αv结合形成跨膜异二聚体,称为整合素αvβ6。ITGB6是整合蛋白αvβ6的β6亚基,是控制整个异二聚体αvβ6表达的关键性亚单位。ITGB6的作用机制涉及其在细胞信号传导中的功能,它通过与特定的细胞外基质蛋白如纤连蛋白、玻连蛋白、腱生蛋白和非活性状态的TGF-β(LAP)结合,激活包括FAK/AKT在内的多种细胞内信号通路。ITGB6的表达在多种疾病中扮演重要角色,包括器官纤维化、癌症和牙周炎等。在癌症中,ITGB6的表达与疾病进展和较差的预后相关,尤其是在肺癌、乳腺癌、结肠癌、胃癌和卵巢癌等多种癌症中。此外,ITGB6在发育、组织修复和肿瘤形成过程中发挥调节上皮重塑的作用,被认为是这些疾病潜在的治疗靶点。

热销产品

ITGB6 Antibody (CSB-PA011890LA01HU)

验证数据

CSB-PA011890LA01HU

Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate(30µg), A549 whole cell lysate(30µg), HT29 whole cell lysate(30µg),HEK293 whole cell lysate(30µg)
All lanes: ITGB6 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 86,75 kDa
Observed band size: 86 kDa
Exposure time: 10s

CSB-PA011890LA01HU

Immunofluorescence staining of A549 cells with CSB-PA011890LA01HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA011890LA01HU

Immunofluorescence staining of A549 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

ITGB6 Antibodies

ITGB6 for Homo sapiens (Human)

ITGB6 Proteins

ITGB6 Proteins for Cavia porcellus (Guinea pig)

ITGB6 Proteins for Homo sapiens (Human)

ITGB6 Proteins for Sus scrofa (Pig)

ITGB6 Proteins for Rattus norvegicus (Rat)

ITGB6 Proteins for Ovis aries (Sheep)

ITGB6 Proteins for Bos taurus (Bovine)