ITGB6
ITGB6,即整合素β6,别名Integrin beta-6。这是一种在上皮细胞中表达的蛋白质,通常与整合素亚基αv结合形成跨膜异二聚体,称为整合素αvβ6。ITGB6是整合蛋白αvβ6的β6亚基,是控制整个异二聚体αvβ6表达的关键性亚单位。ITGB6的作用机制涉及其在细胞信号传导中的功能,它通过与特定的细胞外基质蛋白如纤连蛋白、玻连蛋白、腱生蛋白和非活性状态的TGF-β(LAP)结合,激活包括FAK/AKT在内的多种细胞内信号通路。ITGB6的表达在多种疾病中扮演重要角色,包括器官纤维化、癌症和牙周炎等。在癌症中,ITGB6的表达与疾病进展和较差的预后相关,尤其是在肺癌、乳腺癌、结肠癌、胃癌和卵巢癌等多种癌症中。此外,ITGB6在发育、组织修复和肿瘤形成过程中发挥调节上皮重塑的作用,被认为是这些疾病潜在的治疗靶点。
热销产品
ITGB6 Antibody (CSB-PA011890LA01HU)
验证数据

Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate(30µg), A549 whole cell lysate(30µg), HT29 whole cell lysate(30µg),HEK293 whole cell lysate(30µg)
All lanes: ITGB6 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/20000 dilution
Predicted band size: 86,75 kDa
Observed band size: 86 kDa
Exposure time: 10s

Immunofluorescence staining of A549 cells with CSB-PA011890LA01HU at 1:30, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Immunofluorescence staining of A549 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
ITGB6 Antibodies
ITGB6 for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA011890GA01HU | ITGB6 Antibody | Human | ELISA,WB |
CSB-PA160596 | ITGB6 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA011890LA01HU | ITGB6 Antibody | Human, Mouse | ELISA, WB,IF |
CSB-PA011890LB01HU | ITGB6 Antibody, HRP conjugated | Human | ELISA |
CSB-PA011890LC01HU | ITGB6 Antibody, FITC conjugated | Human | |
CSB-PA011890LD01HU | ITGB6 Antibody, Biotin conjugated | Human | ELISA |
ITGB6 Proteins
ITGB6 Proteins for Cavia porcellus (Guinea pig)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP011890GU1 CSB-EP011890GU1 CSB-BP011890GU1 CSB-MP011890GU1 CSB-EP011890GU1-B |
Recombinant Guinea pig Integrin beta-6 (ITGB6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF011890GU | Recombinant Guinea pig Integrin beta-6 (ITGB6) | in vitro E.coli expression system |
ITGB6 Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-EP011890HU1 CSB-BP011890HU1 CSB-EP011890HU1-B |
Recombinant Human Integrin beta-6 (ITGB6), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
CSB-CF011890HU | Recombinant Human Integrin beta-6 (ITGB6) | in vitro E.coli expression system |
ITGB6 Proteins for Sus scrofa (Pig)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP638458PI CSB-EP638458PI CSB-BP638458PI CSB-MP638458PI CSB-EP638458PI-B |
Recombinant Pig Integrin beta-6 (ITGB6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB6 Proteins for Rattus norvegicus (Rat)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP728115RA CSB-EP728115RA CSB-BP728115RA CSB-MP728115RA CSB-EP728115RA-B |
Recombinant Rat Integrin beta-6 (Itgb6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB6 Proteins for Ovis aries (Sheep)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP803017SH CSB-EP803017SH CSB-BP803017SH CSB-MP803017SH CSB-EP803017SH-B |
Recombinant Sheep Integrin beta-6 (ITGB6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB6 Proteins for Bos taurus (Bovine)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP848316BO CSB-EP848316BO CSB-BP848316BO CSB-MP848316BO CSB-EP848316BO-B |
Recombinant Bovine Integrin beta-6 (ITGB6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |