ITGA11
整合素α11（ITGA11）是整合素家族中负责介导细胞与细胞外基质相互作用的关键成员，常被称为CD抗原或胶原结合受体。该蛋白通过识别特定胶原类型参与组织微环境调控，尤其在成纤维细胞与间质成分的黏附中发挥核心作用。ITGA11活性异常可破坏细胞迁移与组织修复的平衡，与特发性肺纤维化、肝硬化和多种实体瘤的侵袭转移密切相关。ITGA11在肿瘤微环境中通过调节基质硬化程度促进癌细胞存活，这一特性使其成为抗癌药物开发的新焦点。目前已有单克隆抗体类药物进入临床前研究阶段，旨在阻断肿瘤相关成纤维细胞中ITGA11的功能。此外，针对纤维化疾病的抑制剂研发也在探索中，部分小分子化合物在动物模型中展现出减缓器官纤维化的潜力。随着对整合素α11在病理微环境中双重作用的深入理解，该蛋白正逐渐从基础研究走向转化医学的前沿领域。
热销产品
ITGA11 Antibody (CSB-PA033958)
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA033958(ITGA11 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA033958(ITGA11 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse skeletal muscle tissue, Primary antibody: CSB-PA033958(ITGA11 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
ITGA11 Antibodies
ITGA11 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA033958 | ITGA11 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA108283 | ITGA11 Antibody | Human | ELISA,IHC |
| CSB-PA891732ESR1HU | ITGA11 Antibody | Human | ELISA, IHC |
ITGA11 Proteins
ITGA11 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011863MO CSB-EP011863MO CSB-BP011863MO CSB-MP011863MO CSB-EP011863MO-B |
Recombinant Mouse Integrin alpha-11 (Itga11), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGA11 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP891732HU CSB-EP891732HU CSB-BP891732HU CSB-MP891732HU CSB-EP891732HU-B |
Recombinant Human Integrin alpha-11 (ITGA11), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
