IL36RN

IL36RN，即白介素-36受体拮抗剂（Interleukin-36 receptor antagonist），也被称为IL-1家族成员5（IL-1F5）。作为天然免疫调节因子，它通过阻断IL-36与细胞表面受体的结合，维持皮肤、肺等组织的免疫稳态。当该蛋白功能缺失时，IL-36介导的炎症反应会异常增强，导致中性粒细胞过度浸润和组织损伤。
IL36RN的遗传突变与泛发性脓疱型银屑病（GPP）存在强关联，超80%的家族性GPP患者携带其突变基因。临床表现为突发高热伴随全身无菌性脓疱，严重时可危及生命。近年来针对这一靶点的药物研发进展迅速，全球首个IL-36抑制剂斯佩格单抗（spesolimab）已于2022年获FDA批准用于GPP急性发作，III期试验显示超半数患者在用药一周内脓疱完全消退。目前还有多个同类生物制剂和小分子药物处于临床试验阶段，为炎症性皮肤病治疗开辟了新方向。

热销产品

Recombinant Human Interleukin-36 receptor antagonist protein (IL36RN) (CSB-EP866201HU)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

IL36RN Antibody (CSB-PA866201HA01HU)

验证数据

Western blot
All lanes: IL36RN antibody at 16µg/ml + Mouse stomach tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 17 kDa
Observed band size: 17 kDa

Western Blot
Positive WB detected in: Rat kidney tissue
All lanes: IL36RN antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 17 kDa
Observed band size: 17 kDa

IL36RN Antibody

IL36RN Protein

IL36RN ELISA Kit

IL36RN Antibodies

IL36RN for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA866201HA01HU	IL36RN Antibody	Human, Mouse, Rat	ELISA, WB
CSB-PA866201DSR1HU	IL36RN Antibody	Human	ELISA, IHC

IL36RN Proteins

IL36RN Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP866201HU CSB-BP866201HU CSB-MP866201HU CSB-EP866201HU-B	Recombinant Human Interleukin-36 receptor antagonist protein (IL36RN)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP866201HU	Recombinant Human Interleukin-36 receptor antagonist protein (IL36RN)	E.coli
CSB-AP002051HU	Recombinant Human Interleukin-36 receptor antagonist protein (IL36RN)	E.Coli
CSB-AP004411HU	Recombinant Human Interleukin-36 receptor antagonist protein (IL36RN) (Active)	E.coli