IL13RA2
IL13RA2，即白细胞介素13受体α2链。别名CD213a2。它主要在多种肿瘤细胞中表达，包括黑色素瘤、肾细胞癌、肾上腺皮质癌等。IL13RA2的作用机制复杂，最初被认为是诱饵受体，能封闭IL-13，抑制信号传导。但最新研究表明，IL13Rα2在癌细胞中可以介导IL-13信号，通过不依赖STAT6的途径，涉及AP-1和ERK，促进肿瘤的侵袭、转移和TGFβ的产生。IL13RA2的高表达与肿瘤的侵袭性、晚期阶段和癌症转移相关，导致预后不良，特别是在胶质母细胞瘤、结直肠癌和乳腺癌中。IL13RA2被视为癌症治疗的潜在靶点，尤其是在免疫治疗和靶向治疗领域。
热销产品
IL13RA2 Antibody (CSB-PA618901ESR1HU)
验证数据
Western blot
All lanes: Interleukin-13 receptor subunit alpha-2 antibody at 5μg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 44 kDa
Observed band size: 44 kDa
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA618901ESR1HU at dilution of 1:100
IL13RA2 Antibodies
IL13RA2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA011592GA01HU | IL13RA2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA618901ESR1HU | IL13RA2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA618901ESR2HU | IL13RA2 Antibody | Human | ELISA, IHC |
| CSB-PA006276 | IL13RA2 Antibody | Human | WB, ELISA |
| CSB-PA009597 | IL13RA2 Antibody | Human | WB, ELISA |
| CSB-PA239289 | IL13RA2 Antibody | Human | ELISA,IHC |
| CSB-PA569374 | IL13RA2 Antibody | Human | ELISA,IHC |
IL13RA2 Proteins
IL13RA2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011592MO1 CSB-EP011592MO1 CSB-BP011592MO1 CSB-MP011592MO1 CSB-EP011592MO1-B |
Recombinant Mouse Interleukin-13 receptor subunit alpha-2 (Il13ra2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011592MO | Recombinant Mouse Interleukin-13 receptor subunit alpha-2 (Il13ra2) | in vitro E.coli expression system |
IL13RA2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP618901HU CSB-EP618901HU CSB-BP618901HU CSB-MP618901HU CSB-EP618901HU-B |
Recombinant Human Interleukin-13 receptor subunit alpha-2 (IL13RA2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL13RA2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP822098DO CSB-EP822098DO CSB-BP822098DO CSB-MP822098DO CSB-EP822098DO-B |
Recombinant Dog Interleukin-13 receptor subunit alpha-2 (IL13RA2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL13RA2 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP855355RA CSB-EP855355RA CSB-BP855355RA CSB-MP855355RA CSB-EP855355RA-B |
Recombinant Rat Interleukin-13 receptor subunit alpha-2 (Il13ra2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
