IKZF3

IKZF3，即IKAROS家族锌指蛋白3，别名AIO、IMD84、AIOLOS、ZNFN1A3。IKZF3作为转录因子，通过其锌指结构域与DNA结合，参与淋巴细胞的发育和调节B淋巴细胞的增殖和分化。IKZF3能够参与染色质重塑，形成Ikaros同二聚体、Ikaros/Aiolos异二聚体和Aiolos同二聚体，从而调节基因表达。IKZF3在多种造血和免疫细胞中发挥多效性作用，尤其在B淋巴细胞的分化和成熟中占主导地位，介导激活B淋巴细胞对刺激的反应和B细胞增殖。IKZF3的功能紊乱与恶性肿瘤、自身免疫病和免疫缺陷等多种疾病的病理过程相关，其在多发性骨髓瘤中过度表达，导致恶性浆细胞的大量增殖。

热销产品

IKZF3 Antibody (CSB-PA892336DSR1HU)

验证数据

Western blot
All lanes: Zinc finger protein Aiolos antibody at 8μg/ml + HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 59, 52, 54, 30, 48, 50, 55, 42, 36, 33, 43, 31 kDa
Observed band size: 59 kDa

Human Zinc finger protein Aiolos(IKZF3) ELISA kit (CSB-EL011577HU)

验证数据

货号：CSB-EL011577HU

规格：96T/48T

灵敏度：6.25 pg/mL

检测范围：25 pg/mL-1600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.