IGFBP2
IGFBP2，即胰岛素样生长因子结合蛋白2，别名IGFBP-2、IBP-2等。它是由IGFBP2基因编码的蛋白质，在多种细胞和组织中广泛表达。IGFBP2的主要作用机制是通过与胰岛素样生长因子（IGF）结合，调节IGF的生物可用性，影响细胞的生长、分化和凋亡。此外，IGFBP2还能通过影响细胞周期和抑制细胞增殖来发挥其生物学功能。它参与了细胞增殖、细胞迁移、组织修复和肿瘤发展等过程。IGFBP2的异常表达与多种疾病相关，尤其是在肿瘤生物学中，IGFBP2的高表达与肿瘤的侵袭性和预后不良有关。因此，IGFBP2是肿瘤治疗研究中的一个潜在靶点。
热销产品
IGFBP2 Recombinant Monoclonal Antibody (CSB-RA225697A0HU)
验证数据
Western Blot
Positive WB detected in: MCF-7 whole cell lysate
All lanes: IGFBP2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 35 kDa
Observed band size: 35 kDa
IHC image of CSB-RA225697A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
IGFBP2 Antibodies
IGFBP2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA011096GA01HU | IGFBP2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-RA225697A0HU | IGFBP2 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
IGFBP2 Proteins
IGFBP2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011096HU CSB-EP011096HU CSB-BP011096HU CSB-MP011096HU CSB-EP011096HU-B |
Recombinant Human Insulin-like growth factor-binding protein 2 (IGFBP2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IGFBP2 ELISA Kit
IGFBP2 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E04588h | Human insulin-like growth factors binding protein 2,IGFBP-2 ELISA Kit | serum, plasma, tissue homogenates | 0.195 ng/mL |
