HYAL2

透明质酸酶2（Hyaluronidase 2，HYAL2）是人体内降解透明质酸的关键酶之一，常被称为Hyal2或PH-20样酶。该酶主要与HYAL1协同作用于溶酶体，将高分子量透明质酸切割为20-25个糖单位的片段，其活性依赖于酸性环境。HYAL2可通过调控细胞外基质重塑参与组织修复和肿瘤微环境形成，其异常表达与前列腺癌、膀胱癌等恶性肿瘤的侵袭转移密切相关，在乳腺癌中还被发现能通过激活EGFR信号通路促进耐药性形成。HYAL2在心血管疾病领域也受到关注，其介导的透明质酸降解可能影响动脉粥样硬化斑块稳定性。针对透明质酸酶家族的药物开发多聚焦于癌症治疗，例如新型小分子抑制剂SW-173T已进入临床前研究，可通过阻断HYAL2活性抑制肿瘤细胞迁移。由于透明质酸酶家族成员的功能冗余性，针对HYAL2的特异性靶向药物仍面临挑战。

热销产品

Recombinant Human Hyaluronidase-2 (HYAL2) (CSB-MP618635HU)

验证数据

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

HYAL2 Antibody (CSB-PA618635ESR2HU)

验证数据

Western blot
All lanes: Hyaluronidase-2 antibody at 4μg/ml + Mouse lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA618635ESR2HU at dilution of 1:100

Human Hyaluronidase-2(HYAL2) ELISA kit (CSB-EL010919HU)

验证数据

货号：CSB-EL010919HU

规格：96T/48T

灵敏度：0.078 ng/mL

检测范围：0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

HYAL2 Antibody

HYAL2 Protein

HYAL2 ELISA Kit

HYAL2 Antibodies

HYAL2 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA010919GA01HU	HYAL2 Antibody	Human,Mouse,Rat	ELISA,WB,IF
CSB-PA618635ESR2HU	HYAL2 Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA011966	HYAL2 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA014449	HYAL2 Antibody	Human,Mouse,Rat	ELISA,IHC

HYAL2 Proteins

HYAL2 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP618635HU	Recombinant Human Hyaluronidase-2 (HYAL2)	Yeast
CSB-EP618635HU CSB-BP618635HU CSB-EP618635HU-B	Recombinant Human Hyaluronidase-2 (HYAL2)	E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP618635HU	Recombinant Human Hyaluronidase-2 (HYAL2)	Mammalian cell