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HIPK2

HIPK2,即同源结构域相互作用蛋白激酶2,别名PRO0593、hHIPk2。HIPK2是一种丝氨酸/苏氨酸激酶,属于同源结构域相互作用蛋白激酶家族。HIPK2与同源结构域转录因子和许多其他转录因子(如p53)相互作用,可以根据转录因子及其亚细胞定位同时充当共抑制因子和共激活因子。HIPK2可以诱导或抑制转录,调节细胞分化、增殖及凋亡。HIPK2经过泛素化、小泛素样修饰(SUMO)化、乙酰化、磷酸化等翻译后修饰来发挥其生物功能。HIPK2能促进细胞凋亡,是潜在的肿瘤抑制因子和DNA损伤相关激酶,通过磷酸化反应作用于不同的下游靶点来激活凋亡进程。HIPK2还参与组织器官的形成、肿瘤的发生和发展。

热销产品

HIPK2 Antibody (CSB-PA867138LA01HU)

验证数据

CSB-PA867138LA01HU

IHC image of CSB-PA867138LA01HU diluted at 1:500 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA867138LA01HU

IHC image of CSB-PA867138LA01HU diluted at 1:500 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

HIPK2 Antibodies

HIPK2 for Homo sapiens (Human)

HIPK2 Proteins

HIPK2 Proteins for Homo sapiens (Human)

HIPK2 Proteins for Mus musculus (Mouse)

HIPK2 Proteins for Mesocricetus auratus (Golden hamster)