HDAC2
HDAC2，即组蛋白去乙酰化酶2，别名HD 2、HD2、HDAC 2、Hdac2、Histone deacetylase 2 (HD2)、Histone deacetylase 2。它是一种由HDAC2基因编码的酶，属于I类组蛋白去乙酰化酶，主要在细胞核中发挥作用。HDAC2的作用机制是通过去除组蛋白和非组蛋白上的乙酰基团，调控染色质的结构和基因的转录活性。HDAC2的活性受到多种因素的调控，包括代谢产物、细胞信号分子等。HDAC2参与了多种细胞生命活动的调控，包括细胞增殖、分化、代谢和凋亡等。HDAC2的功能异常与多种疾病的发生发展密切相关，尤其是与癌症、神经退行性疾病和心血管疾病等有关。例如，HDAC2的表达水平在某些癌症中发生改变，可能影响肿瘤细胞的增殖和迁移。此外，HDAC2还参与了细胞对氧化应激的响应，通过调控抗氧化基因的表达，保护细胞免受氧化损伤。因此，HDAC2是细胞生物学和疾病研究中的一个重要分子靶点，针对HDAC2的小分子抑制剂正在被开发用于治疗相关疾病。
热销产品
HDAC2 Recombinant Monoclonal Antibody (CSB-RA593846A0HU)
验证数据
Western Blot
Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, MCF-7 whole cell lysate, K562 whole cell lysate
All lanes: HDAC2 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56, 52 kDa
Observed band size: 60 kDa
IHC image of CSB-RA593846A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
HDAC2 Antibodies
HDAC2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA010238GA01HU | HDAC2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA940326 | Phospho-HDAC2 (Ser394) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA295912 | HDAC2 (Ab-394) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA000633 | Phospho-HDAC2 (S394) Antibody | Human,Mouse,Rat,Monkey | WB, ELISA |
| CSB-PA002879 | HDAC2 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA017043 | HDAC2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA260045 | HDAC2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-RA593846A0HU | HDAC2 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-RA949799A0HU | HDAC2 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC, IF |
HDAC2 Proteins
HDAC2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010238MO CSB-BP010238MO CSB-MP010238MO CSB-EP010238MO-B |
Recombinant Mouse Histone deacetylase 2 (Hdac2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HDAC2 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010238CH CSB-EP010238CH CSB-BP010238CH CSB-MP010238CH CSB-EP010238CH-B |
Recombinant Chicken Histone deacetylase 2 (HDAC2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HDAC2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010238HU CSB-EP010238HU CSB-BP010238HU CSB-MP010238HU CSB-EP010238HU-B |
Recombinant Human Histone deacetylase 2 (HDAC2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
