HDAC1
HDAC1，即组蛋白去乙酰化酶1，别名GON 10、HD1、HDAC 1、Histone deacetylase 1、Reduced potassium dependency yeast homolog like 1、RPD3、RPD3L1。它是一种由HDAC1基因编码的酶，属于组蛋白去乙酰化酶家族成员之一，主要在细胞核中发挥作用。HDAC1的作用机制主要是通过去除组蛋白上的乙酰基团，导致染色质结构紧缩，从而抑制特定基因的转录。HDAC1的活性受到多种信号通路的调控，包括Wnt信号通路和PKN1信号通路等。HDAC1参与了细胞周期、细胞分化、细胞凋亡等重要生理过程的调控。HDAC1的异常表达或活性改变与多种疾病的发生发展有关，尤其是与癌症、神经退行性疾病和心血管疾病等密切相关。HDAC1是组蛋白去乙酰化酶抑制剂（HDACi）的主要靶点之一，HDACi能够通过抑制HDAC1的活性，调控细胞凋亡及分化相关蛋白的表达和稳定性，诱导细胞凋亡及分化，成为一类新的抗肿瘤药物。HDAC1的抑制剂在癌症治疗中的应用前景广阔，同时，HDAC1在免疫细胞功能调控及自身免疫病中的作用也受到了广泛关注。
热销产品
Recombinant Human Histone deacetylase 1 (HDAC1) (CSB-EP010235HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010235HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HDAC1.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP010235HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) HDAC1.
HDAC1 Recombinant Monoclonal Antibody (CSB-RA299884A0HU)
验证数据
Western Blot
Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, Jurkat whole cell lysate, HL60 whole cell lysate
All lanes: HDAC1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56 kDa
Observed band size: 60 kDa
HDAC1 Antibodies
HDAC1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA010235GA01HU | HDAC1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA599472 | Phospho-HDAC1 (Ser421) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA157026 | HDAC1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA002877 | HDAC1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA002913 | HDAC1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA005923 | HDAC1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA009171 | Phospho-HDAC1 (S421) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA192926 | HDAC1 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA120655 | HDAC1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA278920 | HDAC1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA134980 | HDAC1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA17869A0Rb | HDAC1 Antibody | Human | ELISA, IHC, IF, ChIP |
| CSB-RA299884A0HU | HDAC1 Recombinant Monoclonal Antibody | Human | ELISA, WB |
HDAC1 Proteins
HDAC1 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010235CH CSB-EP010235CH CSB-BP010235CH CSB-MP010235CH CSB-EP010235CH-B |
Recombinant Chicken Histone deacetylase 1 (HDAC1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HDAC1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010235MO CSB-EP010235MO CSB-BP010235MO CSB-MP010235MO CSB-EP010235MO-B |
Recombinant Mouse Histone deacetylase 1 (Hdac1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HDAC1 Proteins for Strongylocentrotus purpuratus (Purple sea urchin)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010235FOT CSB-EP010235FOT CSB-BP010235FOT CSB-MP010235FOT CSB-EP010235FOT-B |
Recombinant Strongylocentrotus purpuratus Histone deacetylase 1 (HDAC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HDAC1 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010235RA CSB-EP010235RA CSB-BP010235RA CSB-MP010235RA CSB-EP010235RA-B |
Recombinant Rat Histone deacetylase 1 (Hdac1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HDAC1 Proteins for Pongo abelii (Sumatran orangutan)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010235PYX CSB-EP010235PYX CSB-BP010235PYX CSB-MP010235PYX CSB-EP010235PYX-B |
Recombinant Pongo abelii Histone deacetylase 1 (HDAC1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
HDAC1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010235HU CSB-BP010235HU CSB-MP010235HU CSB-EP010235HU-B |
Recombinant Human Histone deacetylase 1 (HDAC1) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP010235HU | Recombinant Human Histone deacetylase 1 (HDAC1) | E.coli |
HDAC1 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010235BO CSB-EP010235BO CSB-BP010235BO CSB-MP010235BO CSB-EP010235BO-B |
Recombinant Bovine Histone deacetylase 1 (HDAC1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
