HAS1
透明质酸合成酶1（Hyaluronan Synthase 1，简称HAS1）是合成透明质酸的关键酶之一，也被称为HA synthase或细胞外基质调节因子。HAS1通过催化葡萄糖醛酸和N-乙酰葡萄糖胺的聚合，生成透明质酸分子，这种黏多糖广泛存在于皮肤、关节液和细胞间质中，具有维持组织水合度、促进创伤修复等功能。HAS1的异常表达与多种病理过程密切相关。在肿瘤微环境中，其过度活跃可能加速癌细胞转移，尤其在乳腺癌和前列腺癌中表现突出；而在类风湿性关节炎患者中，关节滑膜细胞的HAS1活性升高会导致透明质酸碎片堆积，引发炎症反应。近年来针对该靶点的药物开发集中在抑制剂领域，例如通过小分子化合物干扰酶活性，已有部分候选药物进入Ⅱ期临床试验，用于治疗纤维化疾病和特定实体瘤。此外，基于透明质酸的皮肤填充剂和关节润滑剂已在临床广泛应用，但其长效性和稳定性仍依赖对HAS1调控机制的深入研究。
热销产品
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA547529(HAS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA547529(HAS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human testis tissue, Human prostate tissue, Primary antibody: CSB-PA547529(HAS1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
HAS1 Antibodies
HAS1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA547529 | HAS1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA010139LA01HU | HAS1 Antibody | Human | ELISA, IF |
| CSB-PA010139LC01HU | HAS1 Antibody, FITC conjugated | Human | |
| CSB-PA010139LD01HU | HAS1 Antibody, Biotin conjugated | Human | ELISA |
HAS1 Proteins
HAS1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP010139HU1 CSB-EP010139HU1 CSB-BP010139HU1 CSB-MP010139HU1 CSB-EP010139HU1-B |
Recombinant Human Hyaluronan synthase 1 (HAS1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF010139HU | Recombinant Human Hyaluronan synthase 1 (HAS1) | in vitro E.coli expression system |
