GUCY2D
GUCY2D，即鸟苷酸环化酶2D, 也称为Retinal guanylyl cyclase 1、CORD6、GUC1A4、GUC2D、ROS-GC等。
GUCY2D属于腺苷酸环化酶类-鸟苷酸环化酶家族，主要在视网膜的视杆细胞和视锥细胞中催化cGMP的合成，对光传导过程中cGMP的补充起到关键作用，可能还参与膜相关蛋白向光感受器外节膜的运输。
GUCY2D在cGMP生物合成、蛋白质氨基酸磷酸化、受体鸟苷酰基环化酶信号转导途径、细胞内信号转导级联、视觉感知和应答刺激中发挥作用。GUCY2D与视锥视杆营养不良6型(CORD6)和Leber先天性黑朦(LCA)相关，这些疾病均与视觉感知障碍有关。
热销产品
GUCY2D Antibody (CSB-PA010054LA01HU)
验证数据
Western Blot
Positive WB detected in: U251 whole cell lysate
All lanes: GUCY2D antibody at 5.4µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 121 kDa
Observed band size: 121 kDa
Immunofluorescence staining of HepG2 cells with CSB-PA010054LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
GUCY2D Antibodies
GUCY2D for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA010054GA01HU | GUCY2D Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA010054LA01HU | GUCY2D Antibody | Human | ELISA, WB, IF |
| CSB-PA010054LB01HU | GUCY2D Antibody, HRP conjugated | Human | ELISA |
| CSB-PA010054LD01HU | GUCY2D Antibody, Biotin conjugated | Human | ELISA |
