GAD1

GAD1，即谷氨酸脱羧酶1，别名GAD67。这是一种在大脑中表达的酶，负责催化谷氨酸转化为抑制性神经递质γ-氨基丁酸（GABA）。GAD1在神经系统和内分泌系统中表达，涉及突触传递和胰岛素分泌。在肿瘤学中，GAD1在多种肿瘤中异常上调表达，其高表达与结直肠癌的临床分期及生存时间密切相关，并可能在肿瘤细胞适应低氧、低pH微环境中起重要作用。GAD1的异常表达可能通过影响CTCF与DNA的结合，改变基因的甲基化模式，从而激活基因表达。在肿瘤细胞中，GAD1可能通过调节氨基酸稳态来支持细胞增殖，这一作用与其在GABA代谢中的角色不同。GAD1的这些功能在调节神经系统功能和肿瘤生物学中具有重要的生物学意义。

热销产品

GAD1 Antibody (CSB-PA858702ESR1HU)

验证数据

Western blot
All lanes: Glutamate decarboxylase 1 antibody at 8μg/ml + HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 67, 26, 48 kDa
Observed band size: 67 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA858702ESR1HU at dilution of 1:100

Human glutamic acid decarboxylase,GAD ELISA Kit (CSB-E09199h)

验证数据

货号：CSB-E09199h

规格：96T/48T

灵敏度：0.078 ng/mL

检测范围：0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

GAD1 Antibody

GAD1 Protein

GAD1 ELISA Kit

GAD1 Antibodies

GAD1 for Homo sapiens (Human)

产品货号	产品名称	种属反应性	应用类型
CSB-PA858702ESR1HU	GAD1 Antibody	Human	ELISA, WB, IHC
CSB-PA858702ESR2HU	GAD1 Antibody	Human, Rat	ELISA, WB, IHC
CSB-PA087198	GAD1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA142729	GAD1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA008568	GAD1 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA102201	GAD1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA219867	GAD1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA981570	GAD1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC

GAD1 Proteins

GAD1 Proteins for Homo sapiens (Human)

产品货号	产品名称	来源
CSB-YP858702HU CSB-EP858702HU CSB-BP858702HU CSB-MP858702HU CSB-EP858702HU-B	Recombinant Human Glutamate decarboxylase 1 (GAD1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli