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EXOSC10

EXOSC10,即外泌体组分10,别名RRP6、PMSCL、Rrp6p、PM-Scl、PMSCL2、PM/Scl-100等。它是一种核糖核酸外切酶,参与RNA的代谢过程,包括5.8S rRNA的成熟和通过端粒酶对端粒维持的负调节。EXOSC10在胞质溶胶、核腔和转录活性染色质中都有分布,是核外泌体(RNase复合物)的一部分。其作用机制涉及启用3'-5'-核糖核酸外切酶活性,通过降解特定RNA分子来调控基因表达。EXOSC10对维持基因表达的稳定性和参与细胞周期调控具有重要作用,其异常表达与多种疾病相关,包括肝病、癌症和神经系统疾病等。

热销产品

EXOSC10 Antibody (CSB-PA007889LA01HU)

验证数据

CSB-PA007889LA01HU

IHC image of CSB-PA007889LA01HU diluted at 1:300 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

EXOSC10 Antibodies

EXOSC10 for Homo sapiens (Human)