EPHA5
EPHA5蛋白全称为促红细胞生成素肝细胞受体A5，属于Eph受体酪氨酸激酶家族成员，在胚胎发育阶段主导神经轴突导向与突触形成。EPHA5通过与细胞膜表面的ephrin-A配体结合，触发双向信号传导，调控神经细胞迁移和肿瘤微环境重塑。EPHA5在阿尔茨海默病患者海马区呈现异常低表达，其介导的突触修剪功能失调可能与tau蛋白过度磷酸化存在关联。在非小细胞肺癌和胶质母细胞瘤中，EPHA5的高表达与EGFR信号通路形成交叉调控，促进肿瘤细胞侵袭转移。针对该靶点的药物开发聚焦于双特异性抗体技术，通过阻断Ephrin-A5/EPHA5相互作用抑制肿瘤血管生成，已有两款候选药物进入临床前安全性评价阶段。该受体在视网膜退行性病变中表现出神经保护作用，相关基因疗法正在探索其在黄斑变性治疗中的应用潜力。
热销产品
EPHA5 Antibody (CSB-PA007725LA01HU)
验证数据
Western Blot
Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate
All lanes: EPHA5 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 115, 113, 108 kDa
Observed band size: 115 kDa
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA007725LA01HU at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA007725LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
EPHA5 Antibodies
EPHA5 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA002363 | EPHA5 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA007725LA01HU | EPHA5 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA007725LB01HU | EPHA5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007725LC01HU | EPHA5 Antibody, FITC conjugated | Human | |
| CSB-PA007725LD01HU | EPHA5 Antibody, Biotin conjugated | Human | ELISA |
EPHA5 Proteins
EPHA5 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007725CH CSB-EP007725CH CSB-BP007725CH CSB-MP007725CH CSB-EP007725CH-B |
Recombinant Chicken Ephrin type-A receptor 5 (EPHA5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EPHA5 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007725RA CSB-EP007725RA CSB-BP007725RA CSB-MP007725RA CSB-EP007725RA-B |
Recombinant Rat Ephrin type-A receptor 5 (Epha5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EPHA5 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007725HU CSB-EP007725HU CSB-BP007725HU CSB-MP007725HU CSB-EP007725HU-B |
Recombinant Human Ephrin type-A receptor 5 (EPHA5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EPHA5 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP736731MO CSB-EP736731MO CSB-BP736731MO CSB-MP736731MO CSB-EP736731MO-B |
Recombinant Mouse Ephrin type-A receptor 5 (Epha5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
