EDNRA
内皮素受体A型（Endothelin Receptor Type A，简称EDNRA）是一种G蛋白偶联受体，也被称为ET-A或ETAR，主要分布于血管平滑肌细胞。EDNRA选择性结合内皮素-1（ET-1）后，通过激活磷脂酶C和钙离子信号引发血管强烈收缩，同时促进细胞增殖与纤维化，其异常激活与肺动脉高压、雷诺氏综合征密切相关。在肿瘤微环境中，EDNRA的高表达与前列腺癌、卵巢癌的侵袭转移相关，可能通过调控血管新生和基质重塑促进肿瘤进展。
目前全球已上市选择性EDNRA拮抗剂包括安贝生坦（治疗肺动脉高压）和西他生坦，但后者因肝毒性退市。2023年进入III期临床的Zibotentan联合疗法在糖尿病肾病领域展现潜力。研究发现EDNRA抑制剂联合免疫检查点药物可改善肿瘤治疗效果，但需警惕体位性低血压等副作用。该靶点的新剂型开发与联合用药策略成为近年研究热点。
热销产品
Recombinant Human Endothelin-1 receptor (EDNRA) (CSB-CF007403HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
验证数据
Western Blot analysis of COS7 cells using ETAR Polyclonal Antibody
EDNRA Antibodies
EDNRA for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA002447 | EDNRA Antibody | Human,Mouse,Monkey | WB, IHC, IF, ELISA |
| CSB-PA002449 | EDNRA Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA299262 | EDNRA Antibody | Human,Mouse | ELISA,WB,IHC |
EDNRA Proteins
EDNRA Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007403BO1 CSB-EP007403BO1 CSB-BP007403BO1 CSB-MP007403BO1 CSB-EP007403BO1-B |
Recombinant Bovine Endothelin-1 receptor (EDNRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007403BO | Recombinant Bovine Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
EDNRA Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007403RA1 CSB-EP007403RA1 CSB-BP007403RA1 CSB-MP007403RA1 CSB-EP007403RA1-B |
Recombinant Rat Endothelin-1 receptor (Ednra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF007403RA | Recombinant Rat Endothelin-1 receptor (Ednra) | in vitro E.coli expression system |
EDNRA Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP644898PI1 CSB-EP644898PI1 CSB-BP644898PI1 CSB-MP644898PI1 CSB-EP644898PI1-B |
Recombinant Pig Endothelin-1 receptor (EDNRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF644898PI | Recombinant Pig Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
EDNRA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP692301DO1 CSB-EP692301DO1 CSB-BP692301DO1 CSB-MP692301DO1 CSB-EP692301DO1-B |
Recombinant Dog Endothelin-1 receptor (EDNRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF692301DO | Recombinant Dog Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
EDNRA Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP737038MO1 CSB-EP737038MO1 CSB-BP737038MO1 CSB-MP737038MO1 CSB-EP737038MO1-B |
Recombinant Mouse Endothelin-1 receptor (Ednra), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF737038MO | Recombinant Mouse Endothelin-1 receptor (Ednra) | in vitro E.coli expression system |
EDNRA Proteins for Ovis aries (Sheep)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP839205SH1 CSB-EP839205SH1 CSB-BP839205SH1 CSB-MP839205SH1 CSB-EP839205SH1-B |
Recombinant Sheep Endothelin-1 receptor (EDNRA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF839205SH | Recombinant Sheep Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
EDNRA Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007403HU1 | Recombinant Human Endothelin-1 receptor (EDNRA), partial | Yeast |
| CSB-CF007403HU | Recombinant Human Endothelin-1 receptor (EDNRA) | in vitro E.coli expression system |
| CSB-EP007403HU1 CSB-BP007403HU1 CSB-MP007403HU1 CSB-EP007403HU1-B |
Recombinant Human Endothelin-1 receptor (EDNRA), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP007403HU | Recombinant Human Endothelin-1 receptor (EDNRA)-VLPs (Active) | Mammalian cell |
