DYRK4
DYRK4（双特异性酪氨酸磷酸化调节激酶4）属于DYRK激酶家族，在细胞周期调控和应激响应中具有关键作用。该蛋白通过磷酸化下游靶点调控细胞存活与分化，尤其在癌细胞中常通过抑制凋亡通路维持肿瘤细胞增殖。DYRK4异常表达与肝癌、胰腺癌等实体瘤进展相关，其过度激活可能加速肿瘤细胞对化疗药物的耐受性。在神经系统中，DYRK4与阿尔茨海默病相关的tau蛋白异常磷酸化存在潜在关联，可能参与神经纤维缠结的形成。针对DYRK4的药物开发，部分研究机构已筛选出选择性激酶抑制剂，如INDY和化合物5-碘雷帕霉素衍生物，这些候选药物在体外实验中显示出抑制肿瘤生长的潜力。
热销产品
DYRK4 Antibody (CSB-PA882080LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA882080LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA882080LA01HU at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA882080LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
DYRK4 Antibodies
DYRK4 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA007313GA01HU | DYRK4 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA070148 | DYRK4 Antibody | Human | WB, ELISA |
| CSB-PA882080LA01HU | DYRK4 Antibody | Human | ELISA, IHC, IF |
| CSB-PA882080LD01HU | DYRK4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA882080LC01HU | DYRK4 Antibody, FITC conjugated | Human |
DYRK4 Proteins
DYRK4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP882080HU CSB-EP882080HU CSB-BP882080HU CSB-MP882080HU CSB-EP882080HU-B |
Recombinant Human Dual specificity tyrosine-phosphorylation-regulated kinase 4 (DYRK4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
