DUX4
DUX4，即双同源盒4，别名DUXF、FSHD1、FSHDregiongene1。它是一种在早期胚胎发育阶段表达的转录因子，来源于人类基因组中的重复元件。DUX4的作用机制主要是通过其双同源盒结构域与DNA特异性结合，激活下游基因的表达。DUX4在胚胎发育、细胞增殖、分化以及免疫反应中发挥重要作用。异常激活或表达失调与多种疾病相关，如面肩肱型肌营养不良症（FSHD）、某些类型的癌症和病毒感染。DUX4的异常表达可能导致肌细胞凋亡和炎症反应，是FSHD发病机制的关键。此外，DUX4还参与人类胚胎基因组激活和胚胎植入前发育的转录调控。
热销产品
Recombinant Human Double homeobox protein 4 (DUX4), partial (CSB-EP890667HU1)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DUX4 Antibody (CSB-PA890667LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA890667LA01HU at dilution of 1: 100
Western Blot
Positive WB detected in: Hela whole cell lysate, PC-3 whole cell lysate, A549 whole cell lysate, HepG2 whole cell lysate
All lanes: DUX4 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45 kDa
Observed band size: 45 kDa
DUX4 Antibodies
DUX4 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA890667LA01HU | DUX4 Antibody | Human | ELISA, WB, IHC |
| CSB-PA890667LB01HU | DUX4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA890667LC01HU | DUX4 Antibody, FITC conjugated | Human | |
| CSB-PA890667LD01HU | DUX4 Antibody, Biotin conjugated | Human | ELISA |
DUX4 Proteins
DUX4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-BP890667HU1 CSB-MP890667HU1 CSB-EP890667HU1-B |
Recombinant Human Double homeobox protein 4 (DUX4), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP890667HU1 | Recombinant Human Double homeobox protein 4 (DUX4), partial | E.coli |
| CSB-EP890667HU1c7 | Recombinant Human Double homeobox protein 4 (DUX4), partial | E.coli |
| CSB-YP890667HU1 | Recombinant Human Double homeobox protein 4 (DUX4), partial | Yeast |
