DNMT3B
DNMT3B，即DNA甲基转移酶3β，别名ICF、ICF1。DNMT3B是一种DNA甲基转移酶，主要在胚胎发育早期表达和活跃，负责从头甲基化，即在DNA序列中添加甲基基团到胞嘧啶的第五碳原子上。DNMT3B将甲基从S-腺苷甲硫氨酸（SAM）转移到胞嘧啶上，这一过程对基因表达调控、胚胎发育、细胞分化、基因印记、转座子沉默和X染色体失活等生理过程至关重要。DNMT3B在维持DNA甲基化模式、基因表达调控和染色质结构中发挥重要作用。DNMT3B的异常表达或功能失调与多种疾病相关，包括免疫缺陷、中心粒不稳定和面部异常综合征（ICF综合征）以及肿瘤的发生发展。
热销产品
DNMT3B Antibody (CSB-PA883358HA01HU)
验证数据
Western blot
All lanes: DNMT3B antibody at 14µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 96, 94, 87, 81, 89, 95, 78, 82 kDa
Observed band size: 96, 37 kDa
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA883358HA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA883358HA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA883358HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
DNMT3B Antibodies
DNMT3B for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA593881 | DNMT3B Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA002178 | DNMT3B Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA883358HA01HU | DNMT3B Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA883358HB01HU | DNMT3B Antibody, HRP conjugated | Human | ELISA |
| CSB-PA883358HC01HU | DNMT3B Antibody, FITC conjugated | Human | |
| CSB-PA883358HD01HU | DNMT3B Antibody, Biotin conjugated | Human | ELISA |
DNMT3B Proteins
DNMT3B Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP883358HU CSB-EP883358HU CSB-BP883358HU CSB-MP883358HU CSB-EP883358HU-B |
Recombinant Human DNA (cytosine-5)-methyltransferase 3B (DNMT3B), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
