DNMT3A
DNMT3A，即DNA甲基转移酶3α，别名TBRS、HESJAS。DNMT3A是DNA甲基转移酶家族的一员，负责催化DNA的从头甲基化，即在DNA序列中添加甲基基团到胞嘧啶的第五碳原子上。这一过程对基因表达调控、胚胎发育、印记以及X染色体失活等生理过程至关重要。DNMT3A的N端PWWP结构域与染色质相互作用，可结合多种转录抑制物，如辅抑制物RP58、致癌因子PML-RAR或异染色质蛋白HP1B，并与DNMT1相互作用，活化组蛋白去乙酰化酶HDAC1，导致组蛋白脱乙酰化及基因转录抑制。DNMT3A与肿瘤的产生和进展密切相关，其基因突变可能导致细胞基因组DNA异常甲基化，包括基因组DNA总体甲基化水平降低，影响基因表达和细胞功能，与急性髓系白血病等多种血液系统疾病的发生发展密切相关。
热销产品
Recombinant Human DNA (cytosine-5)-methyltransferase 3A (DNMT3A) (CSB-EP897314HU(F3))
验证数据
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DNMT3A Antibody (CSB-PA007083LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded mouse liver tissue using CSB-PA007083LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA007083LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
DNMT3A Antibodies
DNMT3A for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA007083LA01HU | DNMT3A Antibody | Human | ELISA, IHC, IF |
| CSB-PA007083GA01HU | DNMT3A Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA094007 | DNMT3A Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA632606 | DNMT3A Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA522891 | DNMT3A Antibody | Human,Mouse,Rat | ELISA,IHC |
DNMT3A Proteins
DNMT3A Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP007083MO CSB-EP007083MO CSB-BP007083MO CSB-MP007083MO CSB-EP007083MO-B |
Recombinant Mouse DNA (cytosine-5)-methyltransferase 3A (Dnmt3a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DNMT3A Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP633132RA CSB-EP633132RA CSB-BP633132RA CSB-MP633132RA CSB-EP633132RA-B |
Recombinant Rat DNA (cytosine-5)-methyltransferase 3A (Dnmt3a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DNMT3A Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP690180CH CSB-EP690180CH CSB-BP690180CH CSB-MP690180CH CSB-EP690180CH-B |
Recombinant Chicken DNA (cytosine-5)-methyltransferase 3A (DNMT3A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DNMT3A Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP897314HU CSB-BP897314HU CSB-MP897314HU CSB-EP897314HU-B |
Recombinant Human DNA (cytosine-5)-methyltransferase 3A (DNMT3A), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP897314HU | Recombinant Human DNA (cytosine-5)-methyltransferase 3A (DNMT3A), partial | E.coli |
| CSB-EP897314HU(F3) | Recombinant Human DNA (cytosine-5)-methyltransferase 3A (DNMT3A) | E.coli |
