DCLK1
DCLK1，即双皮质素样激酶1，别名CL1、DCLK、CLICK1、DCDC3A、DCAMKL1，由人类DCLK1基因编码，该基因位于13号染色体的q13.3区域。
DCLK1是一种多结构域蛋白，属于蛋白激酶超家族和双皮质素家族，在神经元迁移、逆行运输、神经元凋亡和神经发生等不同的细胞过程中发挥作用。DCLK1与记忆和一般认知能力相关，受脑源性神经营养因子上调。
DCLK1的表达异常与多种疾病相关，包括BandHeterotopia、ZellwegerSyndrome、结肠良性肿瘤、淋巴管瘤和先天性神经系统异常。DCLK1在多种人类癌症中表达水平增加，可能通过调节NOTCH和WNT等发育途径来影响细胞生长。
热销产品
DCLK1 Antibody (CSB-PA006548LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human glioma using CSB-PA006548LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA006548LA01HU at dilution of 1:100
Immunofluorescence staining of MCF-7 cells with CSB-PA006548LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
DCLK1 Antibodies
DCLK1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA006548GA01HU | DCLK1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA231221 | DCLK1 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA876215 | DCLK1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA006548LA01HU | DCLK1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA006548LC01HU | DCLK1 Antibody, FITC conjugated | Human |
DCLK1 Proteins
DCLK1 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006548RA CSB-EP006548RA CSB-BP006548RA CSB-MP006548RA CSB-EP006548RA-B |
Recombinant Rat Serine/threonine-protein kinase DCLK1 (Dclk1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DCLK1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006548HU CSB-EP006548HU CSB-BP006548HU CSB-MP006548HU CSB-EP006548HU-B |
Recombinant Human Serine/threonine-protein kinase DCLK1 (DCLK1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DCLK1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP864369MO CSB-EP864369MO CSB-BP864369MO CSB-MP864369MO CSB-EP864369MO-B |
Recombinant Mouse Serine/threonine-protein kinase DCLK1 (Dclk1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
