CYP27A1
CYP27A1，即细胞色素P450家族27亚家族A成员1。别名CTX、CP27、CYP27，它是一种线粒体酶，主要在肝脏中催化胆汁酸生物合成途径中胆固醇的27-羟基化，这一步骤是合成胆汁酸的替代途径的关键步骤。CYP27A1还参与了胆固醇的27-羟化，生成27-羟基胆固醇，这种物质可以激活肝孤儿受体并诱导巨噬细胞中的胆固醇流出转运蛋白ABCA1和ABCG1，对胆固醇的逆向转运和整体胆固醇稳态具有重要作用。此外，CYP27A1还催化维生素D3的生物活化过程。CYP27A1与多种肿瘤的形成密切相关，包括乳腺癌、前列腺癌、结肠直肠癌和肝癌等。在肿瘤细胞中，CYP27A1的表达可能影响肿瘤的生长和预后，其在肿瘤进程中的作用是一个重要的研究领域。
热销产品
CYP27A1 Antibody (CSB-PA880560LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA880560LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA880560LA01HU at dilution of 1:100
CYP27A1 Antibodies
CYP27A1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA006405GA01HU | CYP27A1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA695994 | CYP27A1 Antibody | Human | ELISA,WB |
| CSB-PA001944 | CYP27A1 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA446866 | CYP27A1 Antibody | Human | ELISA,IHC |
| CSB-PA033966 | CYP27A1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA880560LA01HU | CYP27A1 Antibody | Human | ELISA, IHC |
CYP27A1 Proteins
CYP27A1 Proteins for Oryctolagus cuniculus (Rabbit)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP006405RB CSB-EP006405RB CSB-BP006405RB CSB-MP006405RB CSB-EP006405RB-B |
Recombinant Rabbit Sterol 26-hydroxylase, mitochondrial (CYP27A1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CYP27A1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP880560MO CSB-EP880560MO CSB-BP880560MO CSB-MP880560MO CSB-EP880560MO-B |
Recombinant Mouse Sterol 26-hydroxylase, mitochondrial (Cyp27a1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
