CXCR1
CXCR1对应的蛋白全称为C-X-C趋化因子受体1型，也被称为IL8RA或CD128a。该蛋白主要存在于中性粒细胞表面，能够特异性结合白细胞介素-8（IL-8）等趋化因子，在炎症反应和免疫调节中发挥关键作用。当机体受到感染或损伤时，CXCR1通过传递化学信号引导免疫细胞定向迁移至病灶区域，同时激活炎症介质的释放，参与清除病原体的过程。CXCR1的异常表达与慢性呼吸道疾病、自身免疫性疾病密切相关，其在肿瘤微环境中的促炎特性还可能加速癌细胞扩散。近年来，针对该蛋白的药物开发聚焦于抑制过度活跃的炎症反应，例如小分子拮抗剂Reparixin已进入乳腺癌和胰腺癌的临床试验阶段，但存在靶点选择性不足的局限性。此外，部分研究尝试通过阻断CXCR1与IL-8的相互作用来延缓肺纤维化进展，为相关疾病的精准治疗提供了新方向。
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验证数据
Immunohistochemical analysis of paraffin-embedded Human-liver-cancer, antibody was diluted at 1:100
Immunohistochemical analysis of paraffin-embedded Human-liver-cancer, antibody was diluted at 1:100
Immunohistochemical analysis of paraffin-embedded Human-placenta, antibody was diluted at 1:100
CXCR1 Antibodies
CXCR1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA239685 | CXCR1 Antibody | Human | ELISA,WB |
| CSB-PA821914 | CXCR1 Antibody | Human | IHC,ELISA |
CXCR1 Proteins
CXCR1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP011672HU1 CSB-EP011672HU1 CSB-BP011672HU1 CSB-MP011672HU1 CSB-EP011672HU1-B |
Recombinant Human C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF011672HU | Recombinant Human C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP304062RA1 CSB-EP304062RA1 CSB-BP304062RA1 CSB-MP304062RA1 CSB-EP304062RA1-B |
Recombinant Rat C-X-C chemokine receptor type 1 (Cxcr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF304062RA | Recombinant Rat C-X-C chemokine receptor type 1 (Cxcr1) | in vitro E.coli expression system |
CXCR1 Proteins for Oryctolagus cuniculus (Rabbit)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP325015RB1 CSB-EP325015RB1 CSB-BP325015RB1 CSB-MP325015RB1 CSB-EP325015RB1-B |
Recombinant Rabbit C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF325015RB | Recombinant Rabbit C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP345524GGZ1 CSB-EP345524GGZ1 CSB-BP345524GGZ1 CSB-MP345524GGZ1 CSB-EP345524GGZ1-B |
Recombinant Gorilla gorilla gorilla C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF345524GGZ | Recombinant Gorilla gorilla gorilla C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Pan troglodytes (Chimpanzee)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP345918EQV1 CSB-EP345918EQV1 CSB-BP345918EQV1 CSB-MP345918EQV1 CSB-EP345918EQV1-B |
Recombinant Pan troglodytes C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF345918EQV | Recombinant Pan troglodytes C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Bunopithecus hoolock (Hoolock gibbon) (Hoolock hoolock)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP647407BXO1 CSB-EP647407BXO1 CSB-BP647407BXO1 CSB-MP647407BXO1 CSB-EP647407BXO1-B |
Recombinant Bunopithecus hoolock C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF647407BXO | Recombinant Bunopithecus hoolock C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Pongo pygmaeus (Bornean orangutan)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP648994EXP1 CSB-EP648994EXP1 CSB-BP648994EXP1 CSB-MP648994EXP1 CSB-EP648994EXP1-B |
Recombinant Pongo pygmaeus C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF648994EXP | Recombinant Pongo pygmaeus C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Macaca mulatta (Rhesus macaque)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP652126MOW1 CSB-EP652126MOW1 CSB-BP652126MOW1 CSB-MP652126MOW1 CSB-EP652126MOW1-B |
Recombinant Macaca mulatta C-X-C chemokine receptor type 1 (CXCR1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF652126MOW | Recombinant Macaca mulatta C-X-C chemokine receptor type 1 (CXCR1) | in vitro E.coli expression system |
CXCR1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP800386MO1 CSB-EP800386MO1 CSB-BP800386MO1 CSB-MP800386MO1 CSB-EP800386MO1-B |
Recombinant Mouse C-X-C chemokine receptor type 1 (Cxcr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF800386MO | Recombinant Mouse C-X-C chemokine receptor type 1 (Cxcr1) | in vitro E.coli expression system |
