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CTNNB1

CTNNB1,别名Armadillo、NEDSDV、MRD19、EVR7等。CTNNB1基因位于3号染色体上,编码的蛋白质β-连环蛋白是细胞黏附复合物的重要成分,在上皮细胞中形成粘附连接并介导多种组织的细胞间粘附。CTNNB1在Wnt信号通路中扮演关键角色,控制细胞生长和分化。在没有Wnt信号时,β-连环蛋白被磷酸化后泛素化,并被蛋白酶体降解。Wnt信号存在时,β-连环蛋白积累并在细胞核内与TCF/LEF家族转录因子结合,激活下游基因表达。CTNNB1的突变或异常激活与多种肿瘤的发生发展有关,包括结直肠癌、卵巢癌、肝细胞癌等,是肿瘤治疗的重要靶点。

热销产品

CTNNB1 Recombinant Monoclonal Antibody (CSB-RA155605A0HU)

验证数据

CSB-RA155605A0HU

IHC image of CSB-RA155605A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA155605A0HU

IHC image of CSB-RA155605A0HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CTNNB1 Antibodies

CTNNB1 for Homo sapiens (Human)

CTNNB1 for H, M, R

CTNNB1 for Human, Mouse, Rat

CTNNB1 Proteins

CTNNB1 Proteins for Homo sapiens (Human)

CTNNB1 Proteins for Xenopus laevis (African clawed frog)

CTNNB1 Proteins for Bos taurus (Bovine)

CTNNB1 Proteins for Rattus norvegicus (Rat)

CTNNB1 ELISA Kit

CTNNB1 ELISA Kit for Homo sapiens (Human)

CTNNB1 ELISA Kit for Mus musculus (Mouse)