CLOCK
CLOCK，别名BMAL1、NPAS2。CLOCK由人类CLOCK基因编码，该基因位于第四号染色体的q21.3区域。CLOCK是一种转录因子，与BMAL1（BrainandmuscleARNT-like1）形成异源二聚体，共同激活下游的周期基因和BMAL1自身的表达，从而维持昼夜节律。CLOCK的作用机制涉及与BMAL1结合后，识别并结合到靶基因的E-box元件上，促进这些基因的转录。CLOCK对于调节生物的昼夜节律、睡眠-觉醒周期、代谢以及行为反应等具有重要作用。异常的CLOCK表达与多种生理和病理状态相关，包括睡眠障碍、代谢综合征和某些神经退行性疾病。
热销产品
CLOCK Antibody (CSB-PA005574ESR1HU)
验证数据
Western blot
All lanes: Circadian locomoter output cycles protein kaput antibody at 6μg/ml
Lane 1: Hela whole cell lysate
Lane 2: NIH/3T3 whole cell lysate
Lane 3: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 95 kDa
Observed band size: 95 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA005574ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA005574ESR1HU at dilution of 1:100
CLOCK Antibodies
CLOCK for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA005574ESR1HU | CLOCK Antibody | Human | ELISA, WB, IHC |
| CSB-PA001722 | CLOCK Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA005574EA01HU | CLOCK Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA005574EB01HU | CLOCK Antibody, HRP conjugated | Human | ELISA |
CLOCK Proteins
CLOCK Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005574HU CSB-EP005574HU CSB-BP005574HU CSB-MP005574HU CSB-EP005574HU-B |
Recombinant Human Circadian locomoter output cycles protein kaput (CLOCK), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
