CHRNB1
CHRNB1是神经系统中重要的信号传导分子，其功能异常可能引发多种疾病。CHRNB1全称为胆碱能受体烟碱型β1亚基，也被简称为nAChR β1或神经元乙酰胆碱受体β亚基。它主要分布于神经肌肉接头处，通过与乙酰胆碱结合触发离子通道开放，介导神经冲动向肌肉的传递。若该蛋白发生突变，可能导致先天性肌无力综合征，患者表现为肌肉易疲劳、运动障碍，严重时可影响呼吸功能。研究还发现，CHRNB1表达异常可能与癫痫发作、自主神经功能紊乱存在关联。目前针对该靶点的药物开发集中于小分子调节剂，例如某些烟碱类似物已进入临床前研究，旨在通过稳定受体构象改善神经肌肉传导。此外，传统药物如胆碱酯酶抑制剂虽非直接作用于β1亚基，但可通过提升乙酰胆碱浓度间接影响其功能，这类药物在治疗重症肌无力等疾病中仍发挥重要作用。
热销产品
Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial (CSB-EP005395HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CHRNB1 Antibody (CSB-PA15049A0Rb)
验证数据
Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate
All lanes: CHRNB1 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 57, 50 kDa
Observed band size: 57 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA15049A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA15049A0Rb at dilution of 1:100
Immunofluorescent analysis of PC-3 cells using CSB-PA15049A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CHRNB1 Antibodies
CHRNB1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA005395GA01HU | CHRNB1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA437943 | CHRNB1 Antibody | Human | ELISA,WB |
| CSB-PA006822 | CHRNB1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA15049A0Rb | CHRNB1 Antibody | Human | ELISA, WB, IHC, IF |
CHRNB1 Proteins
CHRNB1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-BP005395HU CSB-MP005395HU CSB-EP005395HU-B |
Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP005395HU | Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial | E.coli |
| CSB-EP005395HUb1 | Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial | E.coli |
| CSB-YP005395HU | Recombinant Human Acetylcholine receptor subunit beta (CHRNB1), partial | Yeast |
