CHRNA4
CHRNA4全称为神经元烟碱型乙酰胆碱受体的α4亚基，常被称为nAChR α4或CHRN4。这类受体广泛分布于中枢神经系统，尤其在丘脑和前额叶皮层中富集，通过结合乙酰胆碱参与神经信号的传递，调控注意力、记忆及觉醒状态。CHRNA4功能异常与多种神经系统疾病密切相关，例如某些家族性夜间额叶癫痫患者的突变位点常出现在该基因区域，导致神经元兴奋性失衡。此外，该受体还涉及尼古丁成瘾机制，吸烟者体内长期尼古丁刺激可能引发受体脱敏，形成依赖性。帕金森病、阿尔茨海默病等神经退行性疾病中也观察到该受体表达水平的变化。近年来，针对α4亚基的药物研究集中在精神类疾病和戒断治疗领域，例如部分抗癫痫药物通过增强受体功能缓解症状，而伐尼克兰等戒烟药物则通过部分激活受体降低尼古丁渴求。不过，由于该受体在中枢的多重调控作用，药物研发需平衡疗效与副作用风险，目前尚无双靶点特异性药物进入临床后期阶段。
热销产品
CHRNA4 Antibody (CSB-PA215866)
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA215866(CHRNA4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA215866(CHRNA4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Lovo cells, 293T cells, Primary antibody: CSB-PA215866(CHRNA4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
CHRNA4 Antibodies
CHRNA4 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA938221 | CHRNA4 Antibody | Human | ELISA,IHC |
| CSB-PA215866 | CHRNA4 Antibody | Human | ELISA,WB,IHC |
CHRNA4 Proteins
CHRNA4 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005390HU CSB-EP005390HU CSB-BP005390HU CSB-MP005390HU CSB-EP005390HU-B |
Recombinant Human Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
