CHRNA1
CHRNA1蛋白全称烟碱型乙酰胆碱受体α1亚基，俗称肌肉型nAChR α亚基，是神经肌肉接头处传递电信号的核心元件。这种跨膜蛋白形成五聚体离子通道，主导运动神经元释放的乙酰胆碱识别，触发骨骼肌收缩反应。CHRNA1功能异常直接导致先天性肌无力综合征，临床表现为眼睑下垂、呼吸肌疲劳等运动障碍，部分突变类型还关联夜间发作性运动障碍。在自身免疫性疾病中，针对该受体的抗体可引发重症肌无力危象。
近年来针对CHRNA1的药物开发聚焦于变构调节技术。新型小分子化合物如GDC-0134通过稳定通道开放状态，在动物模型中成功逆转获得性肌无力症状。基因疗法领域则尝试利用腺相关病毒载体递送正常亚基基因，修复遗传性突变引起的通道功能障碍，目前已完成灵长类动物安全性验证。值得注意的是，某些蛇毒多肽对该受体具有高选择性抑制作用，为开发精准麻醉剂提供了分子模板，但其临床转化仍受限于免疫原性问题。
热销产品
Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial (CSB-BP005386HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CHRNA1 Antibody (CSB-PA11789A0Rb)
验证数据
Western blot
All lanes: CHRNA1 antibody at 2µg/ml + Rat skeletal muscle tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 55, 52 kDa
Observed band size: 55 kDa
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA11789A0Rb at dilution of 1:100
CHRNA1 Antibodies
CHRNA1 for Torpedo californica
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA005386LA01TOT | CHRNA1 Antibody | Torpedo californica | ELISA, WB |
CHRNA1 for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA005386LA01MO | Chrna1 Antibody | Mouse, Human | ELISA, WB |
| CSB-PA005386LB01MO | Chrna1 Antibody, HRP conjugated | Mouse | ELISA |
CHRNA1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA11789A0Rb | CHRNA1 Antibody | Human, Rat | ELISA, WB, IHC |
| CSB-PA11789D0Rb | CHRNA1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA006117 | CHRNA1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA006818 | CHRNA1 Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA169699 | CHRNA1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA587496 | CHRNA1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CHRNA1 Proteins
CHRNA1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005386MO | Recombinant Mouse Acetylcholine receptor subunit alpha (Chrna1), partial | Yeast |
| CSB-EP005386MO | Recombinant Mouse Acetylcholine receptor subunit alpha (Chrna1), partial | E.coli |
| CSB-EP005386MOa2 | Recombinant Mouse Acetylcholine receptor subunit alpha (Chrna1), partial | E.coli |
CHRNA1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005386HUe9 | Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial | Yeast |
| CSB-EP005386HU | Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial | E.coli |
| CSB-EP005386HUc2 | Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial | E.coli |
| CSB-BP005386HU | Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial | Baculovirus |
| CSB-BP005386HU | Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial | Baculovirus |
| CSB-EP005386HU-B | Recombinant Human Acetylcholine receptor subunit alpha (CHRNA1), partial, Biotinylated | E.coli |
CHRNA1 Proteins for Tetronarce californica (Pacific electric ray) (Torpedo californica)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP005386TOT | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | Yeast |
| CSB-EP005386TOTa2 | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | E.coli |
| CSB-BP005386TOT | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | Baculovirus |
| CSB-MP005386TOT | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | Mammalian cell |
CHRNA1 Proteins for Torpedo californica (Pacific electric ray)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-EP005386TOT | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | E.coli |
| CSB-EP005386TOT-B |
Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | In Vivo Biotinylation in E.coli |
| CSB-EP005386TOTe1 | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | E.coli |
| CSB-EP005386TOTb1 | Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial | E.coli |
