CEL
CEL蛋白全称为羧酸酯脂酶,又称胆汁盐刺激脂酶或CEL相关蛋白,主要参与脂肪消化代谢过程。这种酶在胰腺和母乳中高度表达,通过分解膳食中的胆固醇酯与脂溶性维生素,帮助肠道吸收营养,尤其对新生儿生长发育至关重要。其活性异常可能引发代谢紊乱,与慢性胰腺炎、胆道闭锁等消化系统疾病密切相关。研究发现特定遗传变异会导致CEL蛋白截短,进而引发青少年起病的糖尿病合并胰腺萎缩,这类病例被归类为MODY8型糖尿病。
近年发现CEL在胰岛β细胞中的异常积累可能加速糖尿病进程,这为开发相关抑制剂提供了方向。针对CEL缺陷引起的脂肪吸收障碍,已有研究尝试通过重组酶替代疗法改善患者症状,但尚处于动物实验阶段。某些天然黄酮类化合物被发现能调节CEL活性,可能成为代谢性疾病干预的新靶点,目前尚未进入临床转化。
热销产品
CEL Antibody (CSB-PA325708LA01HU)
验证数据

IHC image of CSB-PA325708LA01HU diluted at 1:500 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA325708LA01HU diluted at 1:500 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
CEL Antibodies
CEL for Homo sapiens (Human)
产品货号 | 产品名称 | 种属反应性 | 应用类型 |
---|---|---|---|
CSB-PA005196GA01HU | CEL Antibody | Human | ELISA,WB |
CSB-PA006634 | CEL Antibody | Human | IHC, ELISA |
CSB-PA129151 | CEL Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA194515 | CEL Antibody | Human | ELISA,WB,IHC |
CSB-PA325708LA01HU | CEL Antibody | Human | ELISA, IHC |
CSB-PA325708LB01HU | CEL Antibody, HRP conjugated | Human | ELISA |
CSB-PA325708LC01HU | CEL Antibody, FITC conjugated | Human | |
CSB-PA325708LD01HU | CEL Antibody, Biotin conjugated | Human | ELISA |
CEL Proteins
CEL Proteins for Homo sapiens (Human)
产品货号 | 产品名称 | 来源 |
---|---|---|
CSB-YP325708HU CSB-EP325708HU CSB-BP325708HU CSB-MP325708HU CSB-EP325708HU-B |
Recombinant Human Bile salt-activated lipase (CEL) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |