CD59
CD59，即补体膜攻击复合物抑制因子，别名MAC-IP、MACIF、MEM43等。这是一种糖基磷脂酰肌醇锚定的糖蛋白，由CD59基因编码，广泛分布于人体多种细胞表面，包括红细胞、白细胞、内皮细胞和神经元等。CD59的主要作用是在补体系统激活的最后阶段，通过干扰C8和C9的结合，抑制膜攻击复合物（MAC）的形成，从而保护宿主细胞免受补体介导的溶解。这一作用对于防止自身免疫性疾病的发生至关重要。CD59的异常表达与多种疾病相关，包括阵发性睡眠性血红蛋白尿（PNH）、某些癌症、自身免疫性疾病如糖尿病和多发性硬化等。在肿瘤细胞中，CD59的高表达可能与对抗单克隆抗体治疗的耐药性有关。此外，CD59还参与调节T细胞的粘附和激活，以及在神经系统中可能发挥某些作用。因此，CD59不仅在维持免疫系统平衡中起着关键作用，也可能成为未来治疗某些疾病的潜在靶点。
热销产品
Recombinant Human CD59 glycoprotein (CD59) (CSB-YP004947HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CD59 Recombinant Monoclonal Antibody (CSB-RA046065A0HU)
验证数据
Overlay Peak curve showing Hela cells surface stained with CSB-RA046065A0HU (red line) at 1:50. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1µg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
CD59 Antibodies
CD59 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA004947GA01HU | CD59 Antibody | Human | ELISA,WB,IHC |
| CSB-PA004947ED01HU | CD59 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA004947YA01HU | CD59 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA004947EA01HU | CD59 Antibody | Human | ELISA, IHC, IF |
| CSB-PA004947YB01HU | CD59 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA005228 | CD59 Antibody | Human | WB, ELISA |
| CSB-MA0049471A0m | CD59 Monoclonal Antibody | Human | ELISA,WB,IHC |
| CSB-PA778176 | CD59 Antibody | Human | ELISA,WB,IHC |
| CSB-PA569443 | CD59 Antibody | Human | ELISA,IHC |
| CSB-RA046065A0HU | CD59 Recombinant Monoclonal Antibody | Human | ELISA, FC |
CD59 Proteins
CD59 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004947HU | Recombinant Human CD59 glycoprotein (CD59) | Yeast |
| CSB-EP004947HU | Recombinant Human CD59 glycoprotein (CD59) | E.coli |
| CSB-BP004947HU CSB-MP004947HU CSB-EP004947HU-B |
Recombinant Human CD59 glycoprotein (CD59) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD59 Proteins for Ovis aries (Sheep)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004947SH CSB-EP004947SH CSB-BP004947SH CSB-MP004947SH CSB-EP004947SH-B |
Recombinant Sheep CD59 glycoprotein (CD59) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD59 Proteins for Oryctolagus cuniculus (Rabbit)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004947RB CSB-EP004947RB CSB-BP004947RB CSB-MP004947RB CSB-EP004947RB-B |
Recombinant Rabbit CD59 glycoprotein (CD59) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD59 Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004947PI CSB-EP004947PI CSB-BP004947PI CSB-MP004947PI CSB-EP004947PI-B |
Recombinant Pig CD59 glycoprotein (CD59) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD59 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004947RA CSB-EP004947RA CSB-BP004947RA CSB-MP004947RA CSB-EP004947RA-B |
Recombinant Rat CD59 glycoprotein (Cd59) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD59 Proteins for Callithrix sp. (Marmoset)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004947CBD CSB-EP004947CBD CSB-BP004947CBD CSB-MP004947CBD CSB-EP004947CBD-B |
Recombinant Callithrix sp. CD59 glycoprotein (CD59) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD59 Proteins for Aotus trivirgatus (Night monkey) (Douroucouli)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004947DNI CSB-EP004947DNI CSB-BP004947DNI CSB-MP004947DNI CSB-EP004947DNI-B |
Recombinant Aotus trivirgatus CD59 glycoprotein (CD59) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD59 Proteins for Saimiri sciureus (Common squirrel monkey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004947SWD CSB-EP004947SWD CSB-BP004947SWD CSB-MP004947SWD CSB-EP004947SWD-B |
Recombinant Saimiri sciureus CD59 glycoprotein (CD59) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD59 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP630672DSU CSB-EP630672DSU CSB-BP630672DSU CSB-MP630672DSU CSB-EP630672DSU-B |
Recombinant Chlorocebus aethiops CD59 glycoprotein (CD59) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD59 Proteins for Papio sp. (Baboon)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP631728PBS CSB-EP631728PBS CSB-BP631728PBS CSB-MP631728PBS CSB-EP631728PBS-B |
Recombinant Papio sp. CD59 glycoprotein (CD59) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD59 Proteins for Pongo abelii (Sumatran orangutan)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP719114PYX CSB-EP719114PYX CSB-BP719114PYX CSB-MP719114PYX CSB-EP719114PYX-B |
Recombinant Pongo abelii CD59 glycoprotein (CD59) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD59 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP823365MOV CSB-EP823365MOV CSB-BP823365MOV CSB-MP823365MOV CSB-EP823365MOV-B |
Recombinant Macaca fascicularis CD59 glycoprotein (CD59) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD59 ELISA Kit
CD59 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL004947HU | Human CD59 glycoprotein(CD59) ELISA kit | serum, plasma, tissue homogenates. | 4 ng/ml. |
