CD3G
CD3γ链是T细胞受体复合物的核心组成单元，常被简称为CD3γ或T3G。它与CD3δ、CD3ε等亚基共同形成跨膜蛋白簇，协助T细胞识别抗原信号并启动免疫应答。该蛋白在胸腺细胞发育中不可或缺，其功能缺陷可导致重症联合免疫缺陷病（SCID），表现为反复感染和免疫系统崩溃。CD3γ的异常表达还与T细胞淋巴瘤、系统性红斑狼疮等疾病存在关联。在治疗领域，基于CD3靶点的双特异性抗体药物已取得突破性进展，例如贝林妥欧单抗通过同时结合CD3与肿瘤抗原，可引导T细胞精准杀伤恶性细胞，目前已获批用于白血病临床治疗。此外，利用CD3γ构建的CAR-T疗法在实体瘤研究中展现出潜力，部分项目已进入Ⅱ期临床试验。
热销产品
Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G), partial (CSB-EP004933HU1)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CD3G Antibody (CSB-PA004933LA01HU)
验证数据
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, HEK293 whole cell lysate, NIH/3T3 whole cell lysate, Rat stomach tissue
All lanes: CD3G antibody at 2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 21 kDa
Observed band size: 21 kDa
Immunofluorescent analysis of HepG2 cells using CSB-PA004933LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CD3G Antibodies
CD3G for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA004933GA01HU | CD3G Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA004933LA01HU | CD3G Antibody | Human, Mouse, Rat | ELISA, WB, IF |
| CSB-PA004933LD01HU | CD3G Antibody, Biotin conjugated | Human | ELISA |
CD3G Proteins
CD3G Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004933MO1 CSB-EP004933MO1 CSB-BP004933MO1 CSB-MP004933MO1 CSB-EP004933MO1-B |
Recombinant Mouse T-cell surface glycoprotein CD3 gamma chain (Cd3g), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF004933MO | Recombinant Mouse T-cell surface glycoprotein CD3 gamma chain (Cd3g) | in vitro E.coli expression system |
CD3G Proteins for Ovis aries (Sheep)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004933SH CSB-EP004933SH CSB-BP004933SH CSB-MP004933SH CSB-EP004933SH-B |
Recombinant Sheep T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3G Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004933HU1 CSB-BP004933HU1 CSB-EP004933HU1-B |
Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF004933HU | Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G) | in vitro E.coli expression system |
| CSB-EP004933HU1 | Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | E.coli |
| CSB-MP004933HU1 | Recombinant Human T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | Mammalian cell |
CD3G Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP636709BO CSB-EP636709BO CSB-BP636709BO CSB-MP636709BO CSB-EP636709BO-B |
Recombinant Bovine T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3G Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP735566PI CSB-EP735566PI CSB-BP735566PI CSB-MP735566PI CSB-EP735566PI-B |
Recombinant Pig T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3G Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP737336RA CSB-EP737336RA CSB-BP737336RA CSB-MP737336RA CSB-EP737336RA-B |
Recombinant Rat T-cell surface glycoprotein CD3 gamma chain (Cd3g), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD3G Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP850179MOV | Recombinant Macaca fascicularis T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | Yeast |
| CSB-EP850179MOV CSB-BP850179MOV CSB-MP850179MOV CSB-EP850179MOV-B |
Recombinant Macaca fascicularis T-cell surface glycoprotein CD3 gamma chain (CD3G), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
