CCL20
CCL20蛋白全称为C-C基序趋化因子配体20，又名巨噬细胞炎性蛋白-3α（MIP-3α）或肝脏活化调节趋化因子（LARC）。这种蛋白主要由上皮细胞和免疫细胞分泌，能够特异性结合CCR6受体，引导淋巴细胞、树突状细胞等向炎症部位或黏膜组织迁移。在肠道、皮肤等屏障组织中，CCL20通过维持免疫监视功能参与病原体清除，但其过度表达会引发慢性炎症，与银屑病、溃疡性结肠炎等疾病密切相关。近年来研究发现，该蛋白在肿瘤微环境中异常活跃，尤其在结直肠癌、胰腺癌中可促进免疫抑制和肿瘤转移。
针对CCL20-CCR6轴的药物开发已取得进展，多个单克隆抗体和小分子抑制剂进入临床前研究阶段。其中一款人源化抗体通过阻断CCL20与受体结合，在银屑病动物模型中显著减轻皮肤病变。另有研究尝试将该通路抑制剂与免疫检查点疗法联用，用于增强抗肿瘤效果。值得注意的是，部分天然产物如姜黄素也被证实能下调CCL20表达，为开发植物来源的抗炎药物提供了新思路。
热销产品
Recombinant Human C-C motif chemokine 20 (CCL20), partial (CSB-EP004784HU1c0)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
验证数据
Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-pancreas, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-pancreas, antibody was diluted at 1:200
CCL20 Antibodies
CCL20 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA389153 | CCL20 Antibody | Human,Mouse | IHC,ELISA |
CCL20 Proteins
CCL20 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004784HU CSB-EP004784HU CSB-BP004784HU CSB-MP004784HU CSB-EP004784HU-B |
Recombinant Human C-C motif chemokine 20 (CCL20) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004784HU1 | Recombinant Human C-C motif chemokine 20 (CCL20), partial | E.coli |
| CSB-AP000931HU | Recombinant Human C-C motif chemokine 20 protein (CCL20) | E.Coli |
| CSB-EP004784HU1c0 | Recombinant Human C-C motif chemokine 20 (CCL20), partial | E.coli |
CCL20 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004784RA CSB-EP004784RA CSB-BP004784RA CSB-MP004784RA CSB-EP004784RA-B |
Recombinant Rat C-C motif chemokine 20 (Ccl20) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL20 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP004784MO CSB-EP004784MO CSB-BP004784MO CSB-MP004784MO CSB-EP004784MO-B |
Recombinant Mouse C-C motif chemokine 20 (Ccl20) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP001331MO | Recombinant Mouse C-C motif chemokine 20 protein (Ccl20) | E.Coli |
CCL20 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP840478BO | Recombinant Bovine C-C motif chemokine 20 (CCL20) | Yeast |
| CSB-EP840478BO | Recombinant Bovine C-C motif chemokine 20 (CCL20) | E.coli |
| CSB-BP840478BO CSB-MP840478BO CSB-EP840478BO-B |
Recombinant Bovine C-C motif chemokine 20 (CCL20) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL20 ELISA Kit
CCL20 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E04667h | Human Macrophage Inflammatory Protein-3α,MIP-3α ELISA kit | serum, plasma, cell culture supernates | 3.9 pg/mL |
CCL20 ELISA Kit for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E04668m | Mouse Macrophage Inflammatory Protein 3α,MIP-3α ELISA kit | serum, plasma, tissue homogenates | 9.75 pg/ml |
CCL20 ELISA Kit for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E04669r | Rat macrophage inflammatory protein 3α,MIP-3α ELISA Kit |
