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CA9

碳酸酐酶IX(CA9)是一种跨膜锌金属酶,又称G250或MN蛋白,在维持细胞酸碱平衡中起关键作用。该蛋白通过催化二氧化碳水合反应调节肿瘤微环境pH值,其表达受缺氧诱导因子HIF-1α调控,在透明细胞肾癌中呈现特异性高表达,约95%患者存在CA9过表达现象。作为重要的肿瘤相关抗原,CA9不仅参与PI3K/AKT等促生存信号传导,还与血管生成、肿瘤转移密切相关,其表达水平与肾癌、宫颈癌等多种实体瘤不良预后显著相关。目前针对CA9开发的单克隆抗体Girentuximab已完成III期临床,用于肾癌的放射性免疫显像诊断;小分子抑制剂SLC-0111作为首款进入临床试验的CAIX靶向药物,在乳腺癌、胰腺癌等适应症的II期研究中显示出联合化疗增效潜力。近年来基于CA9的CAR-T疗法和DNA疫苗也进入临床前研究阶段。

热销产品

Recombinant Human Carbonic anhydrase 9 (CA9), partial (CSB-EP614990HUc0)

验证数据

CSB-EP614990HUc0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP614990HUc0

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP614990HUc0 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CA9.

CSB-EP614990HUc0

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP614990HUc0 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CA9.

CA9 Recombinant Monoclonal Antibody (CSB-RA614990A0HU)

验证数据

CSB-RA614990A0HU

IHC image of CSB-RA614990A0HU diluted at 1:118 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-RA614990A0HU

IHC image of CSB-RA614990A0HU diluted at 1:118 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Carbonic Anhydrase 9(CA9) ELISA Kit (CSB-E13266h)

验证数据

CSB-E13266h 标准曲线

货号:CSB-E13266h

规格:96T/48T

灵敏度:7.81 pg/mL

检测范围:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CA9 Antibodies

CA9 for Homo sapiens (Human)

CA9 for H

CA9 Proteins

CA9 Proteins for Homo sapiens (Human)

CA9 Proteins for Mus musculus (Mouse)

CA9 ELISA Kit

CA9 ELISA Kit for Homo sapiens (Human)