BTN2A2
Butyrophilin亚科成员2A2（BTN2A2）是一种调控免疫稳态的关键蛋白，也被称为CD277或嗜乳脂蛋白样分子。它与γδ T细胞表面受体相互作用，通过调节这类特殊免疫细胞的活化阈值，维持机体对病原体和异常细胞的有效防御。BTN2A2在肿瘤微环境中呈现异常表达模式，其表达水平变化可能影响癌细胞免疫逃逸能力，尤其在乳腺癌、卵巢癌中显示出与患者预后的相关性。
在病理机制方面，BTN2A2基因区域的遗传变异与系统性红斑狼疮、1型糖尿病等自身免疫疾病易感性显著相关。基于其独特的免疫检查点特性，多家生物技术公司正开发靶向该蛋白的双特异性抗体，其中AB-102项目已完成临床前研究，通过同时阻断BTN2A2和PD-1信号轴，旨在增强T细胞对实体瘤的杀伤效果。BTN2A2蛋白在神经退行性疾病中的潜在作用也引发关注，阿尔茨海默病患者脑脊液中检测到其特异性异构体异常升高，相关机制仍在深入解析中。
热销产品
Recombinant Human Butyrophilin subfamily 2 member A2 (BTN2A2), partial (CSB-EP848825HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
BTN2A2 Antibody (CSB-PA848825LA01HU)
验证数据
Western blot
All lanes: BTN2A2 antibody at 10μg/ml
Lane 1: MCF-7 whole cell lysate
Lane 2: NIH/3T3 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 60, 38, 29, 46, 36 kDa
Observed band size: 60 kDa
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA848825LA01HU at dilution of 1:100
BTN2A2 Antibodies
BTN2A2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA002871GA01HU | BTN2A2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA848825LA01HU | BTN2A2 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA899996 | BTN2A2 Antibody | Human | ELISA,IHC |
| CSB-PA114726 | BTN2A2 Antibody | Human | ELISA,IHC |
BTN2A2 Proteins
BTN2A2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP848825HU CSB-BP848825HU CSB-MP848825HU CSB-EP848825HU-B |
Recombinant Human Butyrophilin subfamily 2 member A2 (BTN2A2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP848825HU | Recombinant Human Butyrophilin subfamily 2 member A2 (BTN2A2), partial | E.coli |
