BCAT2
支链氨基酸转氨酶2（BCAT2）是一种线粒体酶，主要负责亮氨酸、异亮氨酸和缬氨酸三种支链氨基酸的代谢，通过催化其转氨基反应生成相应的支链α-酮酸。该酶在肝脏、骨骼肌等能量代谢活跃的组织中高表达，因其线粒体定位特征，也被称为BCATm。研究发现，BCAT2通过调控支链氨基酸分解代谢，影响细胞能量供应和蛋白质合成，其异常表达与代谢综合征、糖尿病等疾病密切相关。近年来在肿瘤领域，BCAT2被发现可通过维持白血病干细胞内支链氨基酸水平，促进急性髓系白血病进展，成为潜在治疗靶点。目前针对BCAT2的药物开发尚处于早期阶段，有研究尝试通过小分子抑制剂阻断其酶活性，但尚无进入临床试验的候选药物。值得注意的是，由于支链氨基酸代谢与mTOR信号通路的交互作用，针对该酶的调控可能为代谢性疾病和癌症治疗提供新思路。
热销产品
Recombinant Human Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) (CSB-EP002601HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
BCAT2 Antibody (CSB-PA002601LA01HU)
验证数据
Western blot
All lanes: BCAT2 antibody at 2µg/ml
Lane 1: NIH/3T3 whole cell lysate
Lane 2: Mouse kidney tissue
Lane 3: Mouse spleen tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 45, 34 kDa
Observed band size: 45 kDa
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA002601LA01HU at dilution of 1:100
BCAT2 Antibodies
BCAT2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA002601GA01HU | BCAT2 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA002601LA01HU | BCAT2 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA002601ESR1HU | BCAT2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA842510 | BCAT2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA129399 | BCAT2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
BCAT2 Proteins
BCAT2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP002601HU CSB-BP002601HU CSB-MP002601HU CSB-EP002601HU-B |
Recombinant Human Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP002601HU | Recombinant Human Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) | E.coli |
