BCAM
BCAM蛋白全称为基底细胞黏附分子，也被称为Lutheran血型抗原或CD239，是一种跨膜糖蛋白。该蛋白主要表达于红细胞、上皮细胞及多种肿瘤细胞表面，通过与细胞外基质中的层粘连蛋白结合参与细胞黏附及迁移过程。研究发现BCAM在镰状细胞病中异常活跃，其与血管内皮细胞的相互作用加剧了红细胞的滞留，导致血管阻塞危象的发生。在恶性肿瘤领域，BCAM的高表达与卵巢癌、胰腺癌的转移密切相关，可能通过激活特定激酶促进肿瘤细胞侵袭。近年来针对BCAM的靶向治疗逐渐受到关注，已有研究团队开发出阻断BCAM与层粘连蛋白结合的单克隆抗体，在动物模型中显示出抑制肿瘤转移的效果。2022年一项针对镰状细胞病的II期临床试验中，BCAM抑制剂联合抗凝血疗法使患者疼痛危象发生率降低40%，目前该靶点的双功能抗体药物已进入临床前评估阶段。
热销产品
BCAM Antibody (CSB-PA341920LA01HU)
验证数据
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA341920LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA341920LA01HU at dilution of 1:100
Immunofluorescence staining of HepG2 cells with CSB-PA341920LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
BCAM Antibodies
BCAM for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA005864 | BCAM Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA908140 | BCAM Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA930807 | BCAM Antibody | Human | ELISA,WB |
| CSB-PA341920LA01HU | BCAM Antibody | Human | ELISA, IHC, IF |
BCAM Proteins
BCAM Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP341920HU CSB-EP341920HU CSB-BP341920HU CSB-MP341920HU CSB-EP341920HU-B |
Recombinant Human Basal cell adhesion molecule (BCAM), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
